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Virologica Sinica, 23 (6) : 438-448, 2008
Pathogenetic Consequences of Cytomegalovirus-Host Co-evolution*
Division of Infectious Diseases, School of Public Health, University of California, Berkeley, CA 94720, USA
Co-evolution has been shown to result in an adaptive reciprocal modification in the respective behaviors of interacting populations over time. In the case of host-parasite co-evolution, the adaptive behavior is most evident from the reciprocal change in fitness of host and parasite-manifested in terms of pathogen survival versus host resistance. Cytomegaloviruses and their hosts represent a pairing of populations that has co-evolved over hundreds of years. This review explores the pathogenetic consequences emerging from the behavioral changes caused by co-evolutionary forces on the virus and its host.
  Published online: 5 Dec 2008
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