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Virologica Sinica, 24 (1) : 1-8, 2009
Research Article
Functional Analyses of Mammalian Reovirus Nonstructural Protein μNS*
1. State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
2. Graduate School of the Chinese Academy of Sciences, Beijing 100039, China
 Correspondence:
(376.60KB)  
Abstract
Genome replication of reovirus occurs in cytoplasmic inclusion bodies called viral factories or viroplasms. The viral nonstructural protein μNS, encoded by genome segment M3, is not a component of mature virions, but is expressed to high levels in infected cells and is concentrated in the infected cell factory matrix. Recent studies have demonstrated that μNS plays a central role in forming the matrix of these structures, as well as in recruiting other components to them for putative roles in genome replication and particle assembly.
  Published online: 5 Feb 2009
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