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Virologica Sinica, 25 (2) : 145, 2010
In vivo Inhibition of NAS Preparation on H9N2 Subtype AIV
1. Key Laboratory of New Animal Medicine Project, Chinese Academy of Agricultural Sciences, Lanzhou Insititute of Animal Husbandry & Veterinary Pharamaceutics Science, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China
2. Yunnan Eco-agricultural Research Institute, Kunming 650106, China
NAS preparation, a kind of Chinese herbal medicine found by the Yunnan Eco-agricultural Research Institute, has potential antiviral activity. In this paper, the inhibiting effect of NAS preparation on H9N2 subtype Avian influenza virus (AIV) was investigated in vivo. Chickens infected with H9N2 virus were treated with NAS preparation for 4 days. The virus was then detected by hemoagglutination (HA) test and reverse transcription polymerase chain reaction (RT-PCR). The results showed that no H9N2 virus could be detected at the 7th day when the chickens were treated with 0.2g/kg/d or 0.1g/kg/d of NAS preparation. However the virus could be detected in other chickens without NAS preparation treatment. This result suggested that NAS preparation may be a potential drug candidate to control infection of H9N2 subtype AIV in chickens.
Key Words: NAS preparation;  H9N2 subtype AIV;  HA;  RT-PCR
  Published online: 5 Apr 2010
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