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Virologica Sinica, 25 (4) : 227-245, 2010
Review
Hepatitis C Virus Experimental Model Systems and Antiviral drug Research
Department of Medicine, Section of Hepatology and Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL 60612, USA.
 Correspondence:
(773.60KB)  
Abstract
An estimated 130 million people worldwide are chronically infected with hepatitis C virus (HCV) making it a leading cause of liver disease worldwide. Because the currently available therapy of pegylated interferon-alpha and ribavirin is only effective in a subset of patients, the development of new HCV antivirals is a healthcare imperative. This review discusses the experimental models available for HCV antiviral drug research, recent advances in HCV antiviral drug development, as well as active research being pursued to facilitate development of new HCV-specific therapeutics.
  Published online: 5 Aug 2010
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