Hello guest, Register  |  Sign In
Virologica Sinica, 25 (5) : 316-328, 2010
Research Article
Indinavir Resistance Evolution in One Human Immunodeficiency Virus Type 1 Infected Patient Revealed by Single-Genome Amplification
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China
 Correspondence: lijy@nic.bmi.ac.cn
1.???????? Alexander D C. 1990. A rapid method for determining clone frequency in complex populations using PCR and the Poisson distribution. Nucl Acids Res, 18(24):7453-7454.
2.???????? Bélec L, Piketty C, Si-Mohamed A, et al. 2000. High levels of drug-resistant Human Immunodeficiency Virus variants in patients exhibiting increasing CD4+ T cell counts despite virologic failure of protease inhibitor-containing antiretroviral combination therapy. J Infect Dis, 181(5):1808-1812.
3.???????? Chen Z, Li Y, Schock H B, et al. 1995. Three-dimensional structure of a mutant HIV-1 protease displaying cross-resistance to all protease inhibitors in clinical trials. J Biol Chem, 270(37):21433-21436.
4.???????? Clavel F, Hance A J. 2004. HIV drug resistance. N Engl J Med, 350(10):1023-1035.
5.???????? Coffin J M. 1995. HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. Science, 267:483-489.
6.???????? Condra J H, Holder D J, Schleif W A, et al. 1996.Genetic

correlates of in vivo viral resistance to Indinavir, a Human Immunodeficiency Virus type 1 protease inhibitor. J Virol, 70(12):8270-8276.
7.???????? Descamps D, Joly V, Flandre P, et al. 2005. Genotypic resistance analyses in nucleoside-pretreated patients failing an indinavir containing regimen: results from a randomized comparative trial: (Novavir ANRS 073). J Clin Virol, 33:99-103.
8.???????? Dybul M, Daucher M, Jensen M A, et al. 2003. Genetic characterization of rebounding Human Immunodeficiency Virus type 1 in plasma during multiple interruptions of highly active antiretroviral therapy. J Virol, 77(5):3229-3237.
9.???????? Gunthard H F, Wong J K, Ignacio C C, et al. 1998. Comparative performance of high-density oligonucleotide sequencing and dideoxynucleotide sequencing of HIV type 1 pol from clinical samples. AIDS Res Hum Retroviruses, 14:869-876.
10.????? Kaplan A H, Michael S F, Wehbie R S, et al. 1994. Selection of multiple Human Immunodeficiency Virus type 1 variants that encode viral proteases with decreased sensitivity to an inhibitor of the viral protease. Proc. Natd. Acad. Sci, 91:5597-5601.
  Published online: 5 Oct 2010
Home |  Resources |  About Us |  Support |  Contact Us |  Privacy |  Powered by CanSpeed | 
Copyright © 2015 Virologica Sinica. All rights reserved