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Virologica Sinica, 25 (6) : 381-389, 2010
Review
Isolation and Complete Nucleotide Sequence of the Measles Virus IMB-1 Strain in China*
Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China
 Correspondence: imbcams.lq@gmail.com
(484.46KB)  
Abstract
The complete nucleotide sequence of the measles virus strain IMB-1, which was isolated in China, was determined. As in other measles viruses, its genome is 15,894 nucleotides in length and encodes six proteins. The full-length nucleotide sequence of the IMB-1 isolate differed from vaccine strains (including wild-type Edmonston strain) by 4% –5% at the nucleotide sequence level. This isolate has amino acid variations over the full genome, including in the hemagglutinin and fusion genes. This report is the first to describe the full-length genome of a genotype H1 strain and provide an overview of the diversity of genetic characteristics of a circulating measles virus.
  Published online: 1 Dec 2010
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