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Virologica Sinica, 26 (1) : 40-46, 2011
Effect of siRNAs on HSV-1 Plaque Formation and Relative Expression Levels of RR mRNA*
1. Biomedicine research and development center of Jinan University, Guangdong, Guangzhou, 510632, China
2. Medical College of Jinan University, Guangdong, Guangzhou, 510632, China
3. National Engineering Research Center of Genetic Medicine, Guangdong, Guangzhou, 510632, China
4. National Institute for the Control of Pharmaceutical and Biological Products, Beijing, 100050,China
5. Shanghai GenePharma Co., Ltd, Shanghai, 201203, China
 Correspondence: twang-yf@163.com
RNA interference (RNAi) is a process by which introduced small interfering RNA (siRNA) can cause the specific degradation of mRNA with identical sequences. The human herpes simplex virus type 1 (HSV-1) RR is composed of two distinct homodimeric subunits encoded by UL39 and UL40, respectively. In this study, we applied siRNAs targeting the UL39 and UL40 genes of HSV-1. We showed that synthetic siRNA silenced effectively and specifically UL39 and UL40 mRNA expression and inhibited HSV-1 replication. Our work offers new possibilities for RNAi as a genetic tool for inhibition of HSV-1 replication
  Published online: 5 Feb 2011
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