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Virologica Sinica, 27 (6) : 373, 2012
Letter
An Effective Mannosylated Chitosan Nanoparticle DNA Vaccine for FMD Virus
FMD Quality Control and Quality Assurance Laboratory, Indian Veterinary Research Institute, H A Farm, Hebbal, Bangalore 560 024, Karnataka, India
 Correspondence: subodhkishore@gmail.com
(303.29KB)  
Abstract
We are reporting you an effective DNA vaccine for FMD virus, and it was prepared using mannosylated chitosan (MC) nanoparticles to form the FMDV-pVAC-VP1-OmpA complex particles. These particles were characterized for their physical properties like morphology, size and charge prior evaluating the actual vaccine delivery effect of MC-nanoparticles. The immunological evaluation indicated that the 20 μg of DNA vaccine complexed with MC nano-particles was found optimum in inducing the immune response in G pigs as measured by FMDV specific neutralising antibodies and Th1/Th2 responses using micro SNT and ELISA, respectively.
Received: 16 Nov 2012  Accepted: 5 Jul 2012  Published online: 1 Dec 2012
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