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Virologica Sinica, 28 (3) : 186-189, 2013
Letter
Investigation of the Evolutionary History of the Lyssaviruses
1. Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China

2. Key Laboratory of Agricultural and Environmental Microbiology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, China
 Correspondence: qtang04@sina.com
(553.05KB)  
Abstract
We report the results of evolutionary history estimation of the lyssaviruses based on an analysis of the Glycoprotein (G) sequences gene using the BEAST software package. The most recent common ancestor (TMRCA) of all the lyssavirus strains was estimated to be approximately 5030 years (95% HPD 3988-6069 years), and there was a significant spread of the rabies virus throughout the world range in the last 200 years, consistent with significant time points in development and migration of human civilizations. We speculate that increased and expansion of human migration during this time period may have promote the increase in lyssavirus diversity. In addition, evidence of host switching in lyssavirus history from the Chiroptera to the Carnivora orders was also identified.
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  Accepted: 22 Apr 2013  Published online: 3 Jun 2013
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