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Virologica Sinica, 28 (6) : 318-325, 2013
High-resolution 3D Structures Reveal the Biological Functions of Reoviruses
1. State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China

2. School of Basic Medical Sciences, Wuhan University, Wuhan 430072, China
 Correspondence: qfang@wh.iov.cn
Viruses in the family Reoviridae are non-enveloped particles comprising a segmented double-stranded RNA genome surrounded by a two-layered or multi-layered icosahedral protein capsid. These viruses are classified into two sub-families based on their particle structural organization. Recent studies have focused on high-resolution three-dimensional structures of reovirus particles by using cryo-electron microscopy (cryo-EM) to approach the resolutions seen in X-ray crystallographic structures. The results of cryo-EM image reconstructions allow tracing of most of the protein side chains, and thus permit integration of structural and functional information into a coherent mechanism for reovirus assembly and entry.
Received: 6 Nov 2013  Accepted: 5 May 2013  Published online: 3 Dec 2013
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