Hello guest, Register  |  Sign In
Virologica Sinica, 29 (3) : 139-147, 2014
Review
Viral exploitation of actin:force-generation and scaffolding functions in viral infection
National Center for Biodefense and Infectious Diseases, Department of Molecular and Microbiology, George Mason University, Manassas, VA 20110, USA
 Correspondence: ywu8@gmu.edu
(1463.24KB)  
Abstract
As a fundamental component of the host cellular cytoskeleton, actin is routinely engaged by infecting viruses. Furthermore, viruses from diverse groups, and infecting diverse hosts, have convergently evolved an array of mechanisms for manipulating the actin cytoskeleton for efficacious infection. An ongoing chorus of research now indicates that the actin cytoskeleton is critical for viral replication at many stages of the viral life cycle, including binding, entry, nuclear localization, genomic transcription and reverse transcription, assembly, and egress/dissemination. Specifi cally, viruses subvert the force-generating and macromolecular scaffolding properties of the actin cytoskeleton to propel viral surfi ng, internalization, and migration within the cell. Additionally, viruses utilize the actin cytoskeleton to support and organize assembly sites, and eject budding virions for cell-to-cell transmission. It is the purpose of this review to provide an overview of current research, focusing on the various mechanisms and themes of virus-mediated actin modulation described therein.
Key Words: viral infection;  actin;  cytoskeleton;  cofilin;  LIMK;  Arp2/3;  GTPase
Received: 6 Jun 2014  Accepted: 20 May 2014  Published online: 1 Jun 2014
Home |  Resources |  About Us |  Support |  Contact Us |  Privacy |  Powered by CanSpeed | 
Copyright © 2015 Virologica Sinica. All rights reserved