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Virologica Sinica, 29 (6) : 353-363, 2014
Recent progress in dengue vaccine development
Department of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China
 Correspondence: chenhuicxh@ccmu.edu.cn;anjing@ccmu.edu.cn
Dengue virus (DENV) has four distinct serotypes. DENV infection can result in classic dengue fever and life-threatening dengue hemorrhagic fever/dengue shock syndrome. In recent decades, DENV infection has become an important public health concern in epidemic-prone areas. Vaccination is the most effective measure to prevent and control viral infections. However, several challenges impede the development of effective DENV vaccines, such as the lack of suitable animal models and the antibody-dependent enhancement phenomenon. Although no licensed DENV vaccine is available, signifi cant progress has been made. This review summarizes candidate DENV vaccines from recent investigations.
Received: 24 Dec 2014  Accepted: 13 Nov 2014  Published online: 1 Dec 2014
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