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Virologica Sinica, 30 (1) : 11-18, 2015
Review
Bacteriophage therapy against Enterobacteriaceae
1. China National Research Institute of Food and Fermentation Industries, Beijing 100015, China

2. China Center of Industrial Culture Collection, Beijing 100015, China
 Correspondence: cheng100027@163.com
(805.31KB)  
Abstract
The Enterobacteriaceae are a class of gram-negative facultative anaerobic rods, which can cause a variety of diseases, such as bacteremia, septic arthritis, endocarditis, osteomyelitis, lower respiratory tract infections, skin and soft-tissue infections, urinary tract infections, intra-abdominal infections and ophthalmic infections, in humans, poultry, animals and fi sh. Disease caused by Enterobacteriaceae cause the deaths of millions of people every year, resulting in enormous economic loss. Drug treatment is a useful and effi cient way to control Enterobacteriaceae infections. However, with the abuse of antibiotics, drug resistance has been found in growing number of Enterobacteriaceae infections and, as such, there is an urgent need to find new methods of control. Bacteriophage therapy is an efficient alternative to antibiotics as it employs a different antibacterial mechanism. This paper summarizes the history of bacteriophage therapy, its bacterial lytic mechanisms, and the studies that have focused on Enterobacteriaceae and bacteriophage therapy.
Received: 3 Feb 2015  Accepted: 13 Nov 2014  Published online: 1 Feb 2015
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