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Virologica Sinica, 30 (1) : 19-25, 2015
Review
Survival and proliferation of the lysogenic bacteriophage CTXΦ in Vibrio cholerae
State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
 Correspondence: fanfenxia@icdc.cn
(650.80KB)  
Abstract
The lysogenic phage CTXΦ of Vibrio cholerae can transfer the cholera toxin gene both horizontally (inter-strain) and vertically (cell proliferation). Due to its diversity in form and species, the complexity of regulatory mechanisms, and the important role of the infection mechanism in the production of new virulent strains of V. cholerae, the study of the lysogenic phage CTXΦ has attracted much attention. Based on the progress of current research, the genomic features and their arrangement, the host-dependent regulatory mechanisms of CTXΦ phage survival, proliferation and propagation were reviewed to further understand the phage's role in the evolutionary and epidemiological mechanisms of V. cholerae.
Received: 20 Jan 2015  Accepted: 2 Dec 2014  Published online: 1 Feb 2015
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