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Virologica Sinica, 30 (2) : 146-152, 2015
Research Article
EV71 infection correlates with viral IgG preexisting at pharyngo-laryngeal mucosa in children
1. Mucosal Immunity Research Group, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese
Academy of Sciences, Wuhan 430071, China
2. Changzhou Center for Disease Control and Prevention, Changzhou 213022, China
 Correspondence: liym@wh.iov.cn
(740.75KB)  
Abstract
Enterovirus 71 (EV71) infection causes severe central nervous system damage, particularly for children under the age of 5 years old, which remains a major public health burden worldwide. Clinical data released that children may be repeatedly infected by different members in enterovirus and get even worsen. Mucosa, especially epithelium of alimentary canal, was considered the primary site of EV71 infection. It has been elusive whether the preexsiting viral antibody in mucosa plays a role in EV71 infection. To answer this question, we respectively measured viral antibody response and EV71 RNA copy number of one hundred throat swab specimens from clinically confirmed EV71-infected children. The results released that low-level of mucosal IgG antibody against EV71 broadly existed in young population. More importantly, it further elucidated that the children with mucosal preexsiting EV71 IgG were prone to be infected, which suggested a former viral IgG mediated enhancement of viral infection in vivo.
Key Words: EV71;  clinical infection;  mucosal IgG;  VP1;  VP2;  3D
Received: 14 Dec 2014  Accepted: 10 Mar 2015  Published online: 20 Mar 2015
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