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Virologica Sinica, 30 (3) : 214-217, 2015
Letter
Cellular signaling in sinecatechins-treated external genital and perianal warts: unraveling the mechanism of action of a botanical therapy
1. Department of Dermatology, Baylor College of Medicine,
Houston 77004, USA
2. Department of Dermatology, University of Texas Houston
Health Science Center, Houston 77004, USA
3. Center for Clinical Studies, Houston 77004, USA
 Correspondence: styring@ccstexas.com
(903.00KB)  
Abstract
Taken together with our previous report, current results provide cursory evidence that the sinecatechins’ mechanism of action likely entails some degree of modulation of inflammatory and apoptotic processes, in particular, the NF-κB-pathway. It is possible that sinecatechins also upregulate the host immune response, since the only gene to be significantly upregulated in VR is the pro-lymphocytic IL2; however, further studies are needed to examine the exact pattern of immune regulation. Moreover, since no DEGs were identified in VNR in the prior report, the present study provides putative insight into the expression patterns of patients who are not responsive to sinecatechins.
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  Published online: 25 Mar 2015
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