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Virologica Sinica, 30 (3) : 218-220, 2015
Letter
New prevalence estimate of Torque Teno virus (TTV) infection in healthy population and patients with chronic viral hepatitis in Jiujiang, China
1. Department of Microbiology, School of Basic Medical Science,
Peking University, Beijing 100191, China
2. Jiujiang Women’s & Children’s Hospital, Jiujiang 332000,
China
 Correspondence: ypeng78@bjmu.edu.cn
(706.67KB)  
Abstract
Our results suggest that TTV is extremely common in the general Chinese population, including infants, providing further evidence that TTV is highly prevalent in the general population worldwide(Mancuso et al., 2013). Furthermore, the overall prevalence of TTV infection based on UTR-PCR in healthy infants, healthy adults, and patients with liver disease was almost 2–3 times higher than that obtained by N22-PCR(p < 0.01, Table 1), which highlights both the considerable influence of the PCR primers on the detection of TTV DNA and the benefits of using UTR-PCR to establish the true overall prevalence of TTV infection. On the other h and , our results also indicate the lack of a clear association of TTV infection with chronic viral hepatitis, which strongly suggests that TTV has little potential for causing hepatitis. However, the virulence and pathogenesis of the different genotypes or strains of TTV remain unclear and require further investigation.
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  Published online: 25 Mar 2015
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