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Articles list with the same subject [PI] of Virologica Sinica
Significant Spike-Specific IgG and Neutralizing Antibodies in Mice Induced by a Novel Chimeric Virus-Like Particle Vaccine Candidate for Middle East Respiratory Syndrome Coronavirus
Jiaming Lan, Yao Deng, Jingdong Song, Baoying Huang, Wenling Wang, Wenjie Tan
Middle East respiratory syndrome coronavirus (MERS-CoV) is a major health concern to the general population, with no available licensed therapeutic or vaccine. Virus-like particles (VLPs) comprise viral structural proteins, which represent a safe and highly immunogenic vaccine delivery platform ..., Abstract
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2018 Vol. 33 (5): 453
Identification of Nonstructural Protein 8 as the N-Terminus of the RNADependent RNA Polymerase of Porcine Reproductive and Respiratory Syndrome Virus
Yuanyuan Liu, Yunhao Hu, Yue Chai, Liping Liu, Jiangwei Song, Shaochuan Zhou, Jia Su, Lei Zhou, Xinna Ge, Xin Guo, Jun Han, Hanchun Yang
Porcine reproductive and respiratory syndrome virus (PRRSV) is a member within the family Arteriviridae of the order Nidovirales. Replication of this positive-stranded RNA virus within the host cell involves expression of viral replicase proteins encoded by two ORFs, namely ORF1a ..., Abstract
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2018 Vol. 33 (5): 429
Countrywide Survey for MERS-Coronavirus Antibodies in Dromedaries and Humans in Pakistan
Ali Zohaib, Muhammad Saqib, Muhammad Ammar Athar, Jing Chen, Awais-ur-Rahman Sial, Saeed Khan, Zeeshan Taj, Halima Sadia, Usman Tahir, Muhammad Haleem Tayyab, Muhammad Asif Qureshi, Muhammad Khalid Mansoor, Muhammad Ahsan Naeem1, Bing-Jie Hu, Bilal Ahmed Khan, Ikram Din Ujjan1, Bei Li, Wei Zhang, Yun Luo, Yan Zhu, Cecilia Waruhiu, Iahtasham Khan1, Xing-Lou Yang, Muhammad Sohail Sajid, Victor Max Corman1, 1, Bing Yan, Zheng-Li Shi
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a zoonotic pathogen capable of causing severe respiratory disease in humans. Although dromedary camels are considered as a major reservoir host, the MERS-CoV infection dynamics in camels are not fully understood. Through surveillance in ..., Abstract
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2018 Vol. 33 (5): 410
The Distribution of Different Clades of Seneca Valley Viruses in Guangdong Province, China
Pan Chen, Fan Yang, Weijun Cao, Huanan Liu, Keshan Zhang, Xiangtao Liu, Zhiwen Xu, Zixiang Zhu, Haixue Zheng
Seneca Valley virus (SVV), a newly determined etiological agent of vesicular disease in swine, causes porcine idiopathic disease and occasional acute death in piglets. Recently, an increased number of SVV infection cases have been reported in the United States (US) and China, resulting in ..., Abstract
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2018 Vol. 33 (5): 394
Molecular Epidemiology of Porcine Circovirus Type 3 Infection in Swine Herds in China
Xiangdong Li, Chaolin Zhang, Mingming Qiao, Jiangsong Guo, Guangyuan Xing, Chunxia Jin, Juan Wang, Ming Sun, Kegong Tian
Seven hundred thirty clinical tissue samples collected from diseased pigs in South, Middle, and North China were subjected to detect PCV3 DNA by PCR and results showed that PCV3 positive rate was 14.25%. Six PCV3 genomes were obtained and classified into 3 different clusters. The primary ..., Abstract
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2018 Vol. 33 (4): 373
Tandem 3'UTR Patterns and Gene Expression Profiles of Marc-145 Cells During PRRSV Infection
Ying Wei, Jie Li, Yun Zhang, Chunyi Xue, Yongchang Cao
Porcine reproductive and respiratory syndrome virus (PRRSV) causes substantial economic losses to the global pig industry. Alternative polyadenylation (APA) is a mechanism that diversifies gene expression, which is important for tumorigenesis, development, and cell differentiation. However, it is ..., Abstract
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2018 Vol. 33 (4): 335
Porcine FceRI Mediates Porcine Reproductive and Respiratory Syndrome Virus Multiplication and Regulates the Inflammatory Reaction
Peidian Shi, Lilin Zhang, Jiashun Wang, Dong Lu, Yi Li, Jie Ren, Menglu Shen, Lei Zhang, Jinhai Huang
Porcine reproductive and respiratory syndrome virus (PRRSV) shows characteristic antibody-dependent enhancement (ADE) of infection and causes porcine systemic inflammation, which is similar to a type I allergic reaction; however, the role of porcine FcεRI in ADE is still unclear. In this study ..., Abstract
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2018 Vol. 33 (3): 249
Characteristics of HIV-1 Molecular Epidemiology in Suzhou, China, from 2009 to 2014
Ying Yuan, Shengjie Tang, Yuan Li, Dongmei Yan, Qunxin Peng, Xuerong Ya, Yanhui Song
Suzhou is experiencing a dynamic human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) epidemic. While serology based surveillance systems have reported the spread of HIV/AIDS, detailed tracking of its molecular epidemiology and transmission in populations remains mostly ..., Abstract
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2018 Vol. 33 (2): 209
HearNPV Pseudotyped with PIF1, 2, and 3 from MabrNPV: Infectivity and Complex Stability
George Alliwa Makalliwa, Xi Wang, Huanyu Zhang, Nan Zhang, Cheng Chen, Jiang Li, Fei Deng, Hualin Wang, Manli Wang, Zhihong Hu
Effective oral infection is set off by interaction of a group of conserved per os infectivity factors (PIFs) with larval midgut columnar epithelial cells. We constructed pseudotyped viruses by substituting pif1, pif2 or pif3 genes of Helicoverpa armigera nucleopolyhedrovirus ..., Abstract
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2018 Vol. 33 (2): 187
An Attenuated Highly Pathogenic Chinese PRRS Viral Vaccine Confers Cross Protection to Pigs against Challenge with the Emerging PRRSV NADC30-Like Strain
Hewei Zhang, Mingqi Xia, Wei Wang, Decai Ju, Long Cao, Bai Wu, Xin Wang, Ying Wu, Ni Song, Jiaxin Hu, Changxiao Tian, Shucheng Zhang, Hua Wu
A novel PRRSV strain was isolated in China that was genetically similar to the NADC30 strain which is reported to have spread throughout China. The objective of the present study was to evaluate the cross-protective efficacy of the live vaccine TJM-F92 in young pigs against challenge with a ..., Abstract
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2018 Vol. 33 (2): 153
Serological Evidence of Bat SARS-Related Coronavirus Infection in Humans, China
Ning Wang, Shi-Yue Li, Xing-Lou Yang, Hui-Min Huang, Yu-Ji Zhang, Hua Guo, Chu-Ming Luo, Maureen Miller, Guangjian Zhu, Aleksei A. Chmura, Emily Hagan, Ji-Hua Zhou, Yun-Zhi Zhang, Lin-Fa Wang, Peter Daszak, Zheng-Li Shi
In our previous works, we have reported genetically diverse SARS-related coronaviruses (SARSr-CoV) in a single bat cave, Yunnan province, China, and suggested that some SARSr-CoVs may have high potential to infect humans without the necessity for an intermediate host. In this report, we developed a ..., Abstract
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2018 Vol. 33 (1): 104
Recent progress on chikungunya virus research
Wenxi An, Ningning Ge, Yilin Cao, Jin Sun, Xia Jin
Chikungunya virus (CHIKV) is an arbovirus transmitted by Aedes mosquitos in tropical and subtropical regions across the world. After decades of sporadic outbreaks, it re-emerged in Africa, Asia, India Ocean and America suddenly, causing major regional epidemics recently and becoming a notable ..., Abstract
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2017 Vol. 32 (6): 441
Elevated expression of EBV and TLRs in the brain is associated with Rasmussen’s encephalitis
Xin Wang, Yisong Wang, Dong Liu, Peigang Wang, Dongying Fan, Yuguang Guan, Tianfu Li, Guoming Luan, Jing An
Rasmussen’s encephalitis (RE) is a rare pediatric neurological disorder, the etiology of which remains unclear. It has been speculated that the immunopathogenesis of RE involves damage to neurons, which eventually leads to the occurrence of RE. Viral infection may be a critical factor ..., Abstract
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2017 Vol. 32 (5): 423
Lipids, lipid metabolism and Kaposi’s sarcoma-associated herpesvirus pathogenesis
Lu Dai, Zhen Lin, Wei Jiang, Erik K. Flemington, Zhiqiang Qin
Lipids are essential for mammalian cells to maintain many physiological functions. Emerging evidence has shown that cancer cells can develop specific alterations in lipid biosynthesis and metabolism to facilitate their survival and various malignant behaviors. To date, the precise role ..., Abstract
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2017 Vol. 32 (5): 369
Evaluation of purified recombinant spike fragments for assessment of the presence of serum neutralizing antibodies against a variant strain of porcine epidemic diarrhea virus
Jianwei Hao, Yun Zhang, Shengkun Fang, Zhifen Wen, Xiangbin Zhang, Chunyi Xue, Yongchang Cao
Since 2010,variant strains of porcine epidemic diarrhea virus (PEDV) have caused disasters in the pork industry.The spike (S) protein,as the major immunity-eliciting antigen,has previously been used for serological testing and has been found to correlate significantly with the results of the serum ..., Abstract
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2017 Vol. 32 (4): 307
Coexistence of multiple genotypes of porcine epidemic diarrhea virus with novel mutant S genes in the Hubei Province of China in 2016
Zhe Zeng, Ting-Ting Li, Xin Jin, Fu-Hu Peng, Nian-Hua Song, Gui-Qing Peng, Xing-Yi Ge
The emergence of highly virulent porcine epidemic diarrhea virus (PEDV) variants in China caused huge economic losses in 2010.Since then,large-scale sporadic outbreaks of PED caused by PEDV variants have occasionally occurred in China.However,the molecular diversity and epidemiology of PEDV in ..., Abstract
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2017 Vol. 32 (4): 298
Expression of human cytomegalovirus components in the brain tissues of patients with Rasmussen’s encephalitis
Yao Zhang, Yisong Wang, Sichang Chen, Shuai Chen, Yuguang Guan, Changqing Liu, Tianfu Li, Guoming Luan, Jing An
Rasmussen's encephalitis (RE) is a rare and severe progressive epileptic syndrome with unknown etiology.Infection by viruses,including human cytomegalovirus (HCMV),has been speculated to be a potential trigger for RE.However,no viral antigens have been detected in the brains of patients with ..., Abstract
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2017 Vol. 32 (2): 115
Characterization of two monoclonal antibodies, 38F10 and 44D11, against the major envelope fusion protein of Helicoverpa armigera nucleopolyhedrovirus
Zijiao Zou, Jinliang Liu, Zhiying Wang, Fei Deng, Hualin Wang, Zhihong Hu, Manli Wang, Tao Zhang
The envelope fusion protein F of baculoviruses is a class I viral fusion protein which play a significant role during virus entry into insect cells. F is initially synthesized as a precursor (F0) and then cleaved into a disulfide-linked F1 and F2 subunits during the ..., Abstract
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2016 Vol. 31 (6): 490
Pitfalls of restriction enzyme analysis in identifying, characterizing, typing, and naming viral pathogens in the era of whole genome data, as illustrated by HAdV type 55
Qiwei Zhang, Shoaleh Dehghan, Donald Seto
A recent controversy over the naming of a human adenovirus (HAdV) type 55 as type "11a" (Kajon et al., 2013; Walsh et al., 2010) serves as instructive example to illustrate some of the pitfalls of relying on REA to identify, characterize, type, and name adenoviral pathogens in the era of whole ..., Abstract
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2016 Vol. 31 (5): 448
Structural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitin
Jian Lei, Rolf Hilgenfeld
The papain-like protease (PLpro) of Middle-East respiratory syndrome coronavirus (MERS-CoV) has proteolytic, deubiquitinating, and deISGylating activities. The latter two are involved in the suppression of the antiviral innate immune response of the host cell. To contribute to an ..., Abstract
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2016 Vol. 31 (4): 288
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