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Volume 32 Issue 1
February 2017
    Citation: Rong Guo, Shu Shen, Yanfang Zhang, Junming Shi, Zhengyuan Su, Dan Liu, Jinliang Liu, Juan Yang, Qiguo Wang, Zhihong Hu, Zhang Yujiang, Fei Deng. A new strain of Crimean-Congo hemorrhagic fever virus isolated from Xinjiang, China .VIROLOGICA SINICA, 2017, 32(1) : 80-88.  http://dx.doi.org/10.1007/s12250-016-3936-9
    shu

    A new strain of Crimean-Congo hemorrhagic fever virus isolated from Xinjiang, China

    cstr: 32224.14.s12250-016-3936-9
    • 1.

      The Center for Disease Control and Prevention of Xinjiang Uygur Autonomous' Region, Urumqi, Xinjiang 830002, China

    • 2.

      State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China

    • 3.

      School of Medicine, Wuhan University of Science and Technology, Wuhan 430065, China

    • Corresponding author: Zhang Yujiang, xjsyzhang@163.com, ORCID: 0000-0002-5385-083X
      Fei Deng, df@wh.iov.cn
    • Zhihong Hu, ORCID: 0000-0001-9436-2595
    • These authors contributed equally to this work.
    • Received Date: 21 December 2016
      Accepted Date: 20 February 2017
      Published Date: 27 February 2017
      Available online: 01 February 2017
    • Crimean-Congo hemorrhagic fever virus (CCHFV) is a highly pathogenic tick-borne virus with a fatality rate of up to 50% in humans. CCHFV is widely distributed in countries around the world. Outbreaks of CCHFV infection in humans have occurred in prior years in Xinjiang Province, China. Epidemiological surveys have detected CCHFV RNA in ticks and animals; however, few isolates were identified. In this study, we identified and isolated a new CCHFV strain from Hyalomma asiaticum asiaticum ticks collected from north of Tarim Basin in Xinjiang, China. A preliminary investigation of infection and antigens expression of CCHFV was performed in newborn mice. The target tissues for CCHFV replication in newborn mice were identified. The analysis of the phylogenetic relationships with other Chinese strains suggested that diverse genotypes of CCHFV have circulated in Xinjiang for years. These findings provide important insights into our understanding of CCHFV infection and evolution as well as disease prevention and control for local residents.
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      1. Anagnostou V, Papa A. 2009. Evolution of Crimean-Congo Hemorrhagic Fever virus. Infect Genet Evol, 9: 948-954.
          doi: 10.1016/j.meegid.2009.06.018

      2. Bereczky S, Lindegren G, Karlberg H, Akerstrom S, Klingstrom J, Mirazimi A. 2010. Crimean-Congo hemorrhagic fever virus infection is lethal for adult type Ⅰ interferon receptor-knockout mice. J Gen Virol, 91: 1473-1477.
          doi: 10.1099/vir.0.019034-0

      3. Chen S. 2013. Molecular evolution of Crimean-Congo hemorrhagic fever virus based on complete genomes. J Gen Virol, 94: 843-850.
          doi: 10.1099/vir.0.049379-0

      4. Dai X, Muhtar, Feng CH, Sun SR, Tai XP, Wang XH, Burenmind, Meng WW, Azat, Zhang YJ. 2006. Geography and host distribution of Crimean-Congo hemorrhagic fever in the Tarim Basin. Zhonghua Liu Xing Bing Xue Za Zhi, 27: 1048-1052. (In Chinese)

      5. Deyde VM, Khristova ML, Rollin PE, Ksiazek TG, Nichol ST. 2006. Crimean-Congo hemorrhagic fever virus genomics and global diversity. J Virology, 80: 8834-8842.
          doi: 10.1128/JVI.00752-06

      6. Ergonul O. 2006. Crimean-Congo haemorrhagic fever. Lancet Infect Dis, 6: 203-214.
          doi: 10.1016/S1473-3099(06)70435-2

      7. Feng CH, Bai XH, Liu HB, Li F, Gu Y. 1991. Discovery of Natural Foci of Xinjiang Hemorrhagic Fever in the Southern Margin Area of Junggar Basin, Xinjiang. Endemic Dis. Bull, 6: 52-55. (In Chinese)

      8. Gonzalez JP, Wilson ML, Cornet JP, Camicas JL. 1995. Host-passage-induced phenotypic changes in crimean-congo haemorrhagic fever virus. Res Virol, 146: 131-140.
          doi: 10.1016/0923-2516(96)81082-X

      9. Hewson R, Gmyl A, Gmyl L, Smirnova SE, Karganova G, Jamil B, Hasan R, Chamberlain J, Clegg C. 2004. Evidence of segment reassortment in Crimean-Congo haemorrhagic fever virus. J Gen Virol, 85: 3059-3070.
          doi: 10.1099/vir.0.80121-0

      10. Papa A, Ma B, Kouidou S, Tang Q, Hang C, Antoniadis A. 2002. Genetic characterization of the M RNA segment of Crimean Congo hemorrhagic fever virus strains, China. Emerg Infect Dis, 8: 50-53.
          doi: 10.3201/eid0801.010087

      11. Rodriguez LL, Maupin GO, Ksiazek TG, Rollin PE, Khan AS, Schwarz TF, Lofts RS, Smith JF, Noor AM, Peters CJ, Nichol ST. 1997. Molecular investigation of a multisource outbreak of Crimean-Congo hemorrhagic fever in the United Arab Emirates. Am J Trop Med Hyg, 57: 512-518.

      12. Schwarz TF, Nsanze H, Ameen AM. 1997. Clinical features of Crimean-Congo hemorrhagic fever in the United Arab Emirates. Infection, 25: 364-367.
          doi: 10.1007/BF01740819

      13. Shepherd AJ, Swanepoel R, Leman PA, Shepherd SP. 1986. Comparison of methods for isolation and titration of Crimean-Congo hemorrhagic fever virus. J Clin Microbiol, 24: 654-656.

      14. Sun S, Dai X, Aishan M, Wang X, Meng W, Feng C, Zhang F, Hang C, Hu Z, Zhang Y. 2009. Epidemiology and phylogenetic analysis of Crimean-Congo hemorrhagic fever viruses in xinjiang, china. J Clin Microbiol, 47: 2536-2543.
          doi: 10.1128/JCM.00265-09

      15. Tamura K, Stecher G, Peterson D, Filipski A, Kumar S. 2013. MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. Mol Biol Evol, 30: 2725-2729.
          doi: 10.1093/molbev/mst197

      16. Tang Q, Zhao XQ, Wang HY, Simayi B, Zhang YZ, Saijo M, Morikawa S, Liang GD, Kurane I. 2005. Molecular epidemiology of Xinjiang hemorrhagic fever viruses. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi, 19: 312-318. (In Chinese)

      17. Yen YC, Kong LX, Lee L, Zhang YQ, Li F, Cai BJ, Gao SY. 1985. Characteristics of Crimean-Congo hemorrhagic fever virus (Xinjiang strain) in China. Am J Trop Med Hyg, 34: 1179-1182.

      18. Zhou Z, Deng F, Han N, Wang H, Sun S, Zhang Y, Hu Z, Rayner S. 2013a. Reassortment and migration analysis of CrimeanCongo haemorrhagic fever virus. J Gen Virol, 94: 2536-2548.
          doi: 10.1099/vir.0.056374-0

      19. Zhou Z, Meng W, Deng F, Xia H, Li T, Sun S, Wang M, Wang H, Zhang Y, Hu Z. 2013b. Complete genome sequences of two crimean-congo hemorrhagic Fever viruses isolated in China. Genome Announc, 1. pii: e00571-13

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      A new strain of Crimean-Congo hemorrhagic fever virus isolated from Xinjiang, China

        Corresponding author: Zhang Yujiang, xjsyzhang@163.com
        Corresponding author: Fei Deng, df@wh.iov.cn
      • Zhihong Hu, ORCID: 0000-0001-9436-2595
      • 1. The Center for Disease Control and Prevention of Xinjiang Uygur Autonomous' Region, Urumqi, Xinjiang 830002, China
      • 2. State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
      • 3. School of Medicine, Wuhan University of Science and Technology, Wuhan 430065, China
      • Received Date: 21 December 2016
      • Accepted Date: 20 February 2017
      • Published Date: 27 February 2017

      Abstract: Crimean-Congo hemorrhagic fever virus (CCHFV) is a highly pathogenic tick-borne virus with a fatality rate of up to 50% in humans. CCHFV is widely distributed in countries around the world. Outbreaks of CCHFV infection in humans have occurred in prior years in Xinjiang Province, China. Epidemiological surveys have detected CCHFV RNA in ticks and animals; however, few isolates were identified. In this study, we identified and isolated a new CCHFV strain from Hyalomma asiaticum asiaticum ticks collected from north of Tarim Basin in Xinjiang, China. A preliminary investigation of infection and antigens expression of CCHFV was performed in newborn mice. The target tissues for CCHFV replication in newborn mice were identified. The analysis of the phylogenetic relationships with other Chinese strains suggested that diverse genotypes of CCHFV have circulated in Xinjiang for years. These findings provide important insights into our understanding of CCHFV infection and evolution as well as disease prevention and control for local residents.

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