Citation: Lin Cheng, Liuqing Yang, Miao Wang, Yabo Peng, Haiyan Wang, Xiaoxiang Yang, Juanjuan Zhao, Mingxia Zhang, Fuxiang Wang, Zheng Zhang. Isolation and characterization of mpox virus from the first mpox case in Shenzhen, China .VIROLOGICA SINICA, 2024, 39(2) : 335-337.  http://dx.doi.org/10.1016/j.virs.2024.01.004

Isolation and characterization of mpox virus from the first mpox case in Shenzhen, China

  • Highlights
    1. We reported the first MPXV strain hMpxV/China/SZ-SZTH42/2023 isolated in southern China.
    2. The isolate SZTH42 belongs to C.1 lineage of clade IIb, representing the currently prevalent IIb branch strain worldwide.
    3. This study provides key resources and technical platforms for further research as well as antiviral drugs and vaccines development.

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  • 10.1016j.virs.2024.01.004-ESM.doc
    1. Gong Q, Wang C, Chuai X, Chiu S. 2022. Monkeypox virus:A re-emergent threat to humans. Virol Sin, 37:477-482.

    2. Huang B, Zhao H, Song J, Zhao L, Deng Y, Wang W, Lu R, Wang W, Ren J, Ye F, Tian H, Wu G, Ling H, Tan W. 2022. Isolation and characterization of monkeypox virus from the first case of monkeypox-chongqing municipality, china, 2022. China CDC Wkly, 4:1019-1024.

    3. Jia H, Sha T, Zhao S, Su W, Liu P, Zhen R, Li P, Zhou L, Xu Y, Wen Y, Chi L, Di B, Li P, Chen H, Qin P. 2023. Genomic and epidemiological perspectives on the first local sporadic cases of mpox in china. Emerg Microbes Infect, 12:2245932.

    4. Ju B, Zhang Q, Ge J, Wang R, Sun J, Ge X, Yu J, Shan S, Zhou B, Song S, Tang X, Yu J, Lan J, Yuan J, Wang H, Zhao J, Zhang S, Wang Y, Shi X, Liu L, Zhao J, Wang X, Zhang Z, Zhang L. 2020. Human neutralizing antibodies elicited by sars-cov-2 infection. Nature, 584:115-119.

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    6. Lustig S, Fogg C, Whitbeck JC, Moss B. 2004. Synergistic neutralizing activities of antibodies to outer membrane proteins of the two infectious forms of vaccinia virus in the presence of complement. Virology, 328:30-35.

    7. Payne LG. 1979. Identification of the vaccinia hemagglutinin polypeptide from a cell system yielding large amounts of extracellular enveloped virus. J Virol, 31:147-155.

    8. Russo AT, Grosenbach DW, Chinsangaram J, Honeychurch KM, Long PG, Lovejoy C, Maiti B, Meara I, Hruby DE. 2021. An overview of tecovirimat for smallpox treatment and expanded anti-orthopoxvirus applications. Expert Rev Anti Infect Ther, 19:331-344.

    9. Sun S, Cai Y, Song TZ, Pu Y, Cheng L, Xu H, Sun J, Meng C, Lin Y, Huang H, Zhao F, Zhang S, Gao Y, Han JB, Feng XL, Yu DD, Zhu Y, Gao P, Tang H, Zhao J, Zhang Z, Yang J, Hu Z, Fu YX, Zheng YT, Peng H. 2021. Interferon-armed rbd dimer enhances the immunogenicity of rbd for sterilizing immunity against sars-cov-2. Cell Res, 31:1011-1023.

    10. Yang L, Chen Y, Li S, Zhou Y, Zhang Y, Pei R, Chen X, Wang Y. 2023. Immunization of mice with vaccinia virus tiantan strain yields antibodies cross-reactive with protective antigens of monkeypox virus. Virol Sin, 38:162-164.

    11. Zhang RR, Wang ZJ, Zhu YL, Tang W, Zhou C, Zhao SQ, Wu M, Ming T, Deng YQ, Chen Q, Jin NY, Ye Q, Li X, Qin CF. 2023. Rational development of multicomponent mrna vaccine candidates against mpox. Emerg Microbes Infect, 12:2192815.

    12. Zhou B, Wang H, Cheng L, Zhao C, Zhou X, Liao X, Ge X, Liu L, Lu X, Ju B, Zhang Z. 2023. Two long-lasting human monoclonal antibodies cross-react with monkeypox virus a35 antigen. Cell Discov, 9:50.

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    Isolation and characterization of mpox virus from the first mpox case in Shenzhen, China

      Corresponding author: Fuxiang Wang, wangfuxiang999@163.com
      Corresponding author: Zheng Zhang, zhangzheng1975@aliyun.com
    • a. Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, 518112, China;
    • b. Department of Infectious Diseases, Shenzhen Third People's Hospital, Shenzhen 518112, China;
    • c. The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen 518112, China

    Abstract: Highlights
    1. We reported the first MPXV strain hMpxV/China/SZ-SZTH42/2023 isolated in southern China.
    2. The isolate SZTH42 belongs to C.1 lineage of clade IIb, representing the currently prevalent IIb branch strain worldwide.
    3. This study provides key resources and technical platforms for further research as well as antiviral drugs and vaccines development.

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