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Citation: Minglong Liang, Zongmei Wang, Chuanjian Wu, Sidong Xiong, Ling Zhao, Chunsheng Dong. A single dose of recombinant VSV-RABVG vaccine provides full protection against RABV challenge [J].VIROLOGICA SINICA, 2022, 37(3) : 455-458.  http://dx.doi.org/10.1016/j.virs.2022.02.008

A single dose of recombinant VSV-RABVG vaccine provides full protection against RABV challenge

  • Highlights:
    1. A replication-competent recombinant VSV with RABV-G protein replacement was generated.
    2. Single dose of VSV-RABVG immunization induce potent antigen-specific humoral immune response, especially the virus neutralizing antibodies.
    3. Mice intranasally immunized with single dose of VSV-RABVG were 100% protected upon RABV challenge.

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  • 10.1016j.virs.2022.02.008-ESM.doc
    1. Bommier, E., Chapat, L., Guiot, A.L., Hilaire, F., Cariou, C., Poulet, H., Pialot, D., De Luca, K., 2020. Multivariate analysis of the immune response to different rabies vaccines. Vet. Immunol. Immunopathol. 220, 109986.

    2. China CDC, 2016. Technical guidelines for human rabies prevention and contro. https://www.chinacdc.cn/zxdt/201602/t20160201_125012.html (accessed on 20 June 2021).

    3. Douglas S, Lyles IVK, Rupprecht CE. 2013. Rhabdoviridae, p 885-922. In Knipe DM, Howley PM, Cohen JL, Griffin DE, Lamb RA, Martin MA, Racaniello VR, Roizman B (ed), Fields Virology, 6th ed, vol 1. Lippincott Williams and Wilkens, Philadelphia, PA

    4. Ertl, H.C.J., 2019. New rabies vaccines for use in humans. Vaccines (Basel) 7 (2), 54.

    5. Ge, J., Wang, X., Tao, L., Wen, Z., Feng, N., Yang, S., Xia, X., Yang, C., Chen, H., Bu, Z., 2011. Newcastle disease virus-vectored rabies vaccine is safe, highly immunogenic, and provides long-lasting protection in dogs and cats. J. Virol. 85, 8241-8252.

    6. Hampson, K., Coudeville, L., Lembo, T., Sambo, M., Kieffer, A., Attlan, M., Barrat, J., Blanton, J.D., Briggs, D.J., Cleaveland, S., Costa, P., Freuling, C.M., Hiby, E., Knopf, L., Leanes, F., Meslin, F.X., Metlin, A., Miranda, M.E., Muller, T., Nel, L.H., Recuenco, S., Rupprecht, C.E., Schumacher, C., Taylor, L., Vigilato, M.A., Zinsstag, J., Dushoff, J., Global Alliance for Rabies Control Partners for Rabies, P, 2015. Estimating the global burden of endemic canine rabies. PLoS Neglected Trop. Dis. 9, e0003709.

    7. Lawson, N.D., Stillman, E.A., Whitt, M.A., Rose, J.K., 1995. Recombinant vesicular stomatitis viruses from DNA. Proc. Natl. Acad. Sci. U. S. A. 92, 4477-4481.

    8. Lebrun, A., Garcia, S., Li, J., Kean, R.B., Hooper, D.C., 2017. Protection against CNStargeted rabies virus infection is dependent upon type-1 immune mechanisms induced by live-attenuated rabies vaccines. Tropical Med. Infect. Dis. 2, 22.

    9. Li, Y., Zhao, L., Sui, B., Luo, Z., Zhang, Y., Wang, Y., 2020. Recombinant rabies virus overexpressing OX40-ligand enhances humoral immune responses by increasing T follicular helper cells and germinal center B cells. Vaccines 8, 144.

    10. Park, J.E., Shin, H.J., 2021. Immunogenicity of replication-deficient vesicular stomatitis virus based rabies vaccine in mice. Vet. Q. 41, 202-209.

    11. Singh, R., Singh, K.P., Cherian, S., Saminathan, M., Kapoor, S., Manjunatha Reddy, G.B., Panda, S., Dhama, K., 2017. Rabies-epidemiology, pathogenesis, public health concerns and advances in diagnosis and control:a comprehensive review. Vet. Q. 37, 212-251.

    12. WHO, 2013. WHO Expert Consultation on Rabies. Second report. World Health Organ Tech Rep Ser, pp. 1-139. back cover.

    13. Wu, C., Wu, M., Liang, M., Xiong, S., Dong, C., 2019. A novel oncolytic virus engineered with PD-L1 scFv effectively inhibits tumor growth in a mouse model. Cell. Mol. Immunol. 16, 780-782.

    14. Wu, F., Fan, X., Yue, Y., Xiong, S., Dong, C., 2014. A vesicular stomatitis virus-based mucosal vaccine promotes dendritic cell maturation and elicits preferable immune response against coxsackievirus B3 induced viral myocarditis. Vaccine 32, 3917-3926.

    15. Yahalom-Ronen, Y., Tamir, H., Melamed, S., Politi, B., Shifman, O., Achdout, H., Vitner, E.B., Israeli, O., Milrot, E., Stein, D., Cohen-Gihon, I., Lazar, S., Gutman, H., Glinert, I., Cherry, L., Vagima, Y., Lazar, S., Weiss, S., Ben-Shmuel, A., Avraham, R., Puni, R., Lupu, E., Bar-David, E., Sittner, A., Erez, N., Zichel, R., Mamroud, E., Mazor, O., Levy, H., Laskar, O., Yitzhaki, S., Shapira, S.C., Zvi, A., Beth-Din, A., Paran, N., Israely, T., 2020. A single dose of recombinant VSV-G-spike vaccine provides protection against SARS-CoV-2 challenge. Nat. Commun. 11, 6402.

    16. Zhang, Y., Yang, J., Li, M., Cui, M., Fu, Z.F., Zhao, L., Zhou, M., 2019. A recombinant rabies virus expressing fms-like tyrosine kinase 3 ligand (Flt3L) induces enhanced immunogenicity in mice. Virol. Sin. 34, 662-672.

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    A single dose of recombinant VSV-RABVG vaccine provides full protection against RABV challenge

      Corresponding author: Sidong Xiong, sdxiong@suda.edu.cn
      Corresponding author: Ling Zhao, zling604@yahoo.com
      Corresponding author: Chunsheng Dong, chunshengdong@suda.edu.cn
    • a Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123, China;
    • b State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China;
    • c Key Laboratory of Preventive Veterinary Medicine of Hubei Province, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China

    Abstract: Highlights:
    1. A replication-competent recombinant VSV with RABV-G protein replacement was generated.
    2. Single dose of VSV-RABVG immunization induce potent antigen-specific humoral immune response, especially the virus neutralizing antibodies.
    3. Mice intranasally immunized with single dose of VSV-RABVG were 100% protected upon RABV challenge.

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