Citation: Ruikun Du, Qinghua Cui, Zinuo Chen, Xiujuan Zhao, Xiaojing Lin, Lijun Rong. Revisiting influenza A virus life cycle from a perspective of genome balance .VIROLOGICA SINICA, 2023, 38(1) : 1-8.

Revisiting influenza A virus life cycle from a perspective of genome balance

  • Corresponding author: Ruikun Du,
    Lijun Rong,
  • Received Date: 05 August 2022
    Accepted Date: 18 October 2022
    Available online: 27 October 2022
  • Influenza A virus (IAV) genome comprises eight negative-sense RNA segments, of which the replication is well orchestrated and the delicate balance of multiple segments are dynamically regulated throughout IAV life cycle. However, previous studies seldom discuss these balances except for functional hemagglutinin-neuraminidase balance that is pivotal for both virus entry and release. Therefore, we attempt to revisit IAV life cycle by highlighting the critical role of "genome balance". Moreover, we raise a "balance regression" model of IAV evolution that the virus evolves to rebalance its genome after reassortment or interspecies transmission, and direct a "balance compensation" strategy to rectify the "genome imbalance" as a result of artificial modifications during creation of recombinant IAVs. This review not only improves our understanding of IAV life cycle, but also facilitates both basic and applied research of IAV in future.

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    Revisiting influenza A virus life cycle from a perspective of genome balance

      Corresponding author: Ruikun Du,
      Corresponding author: Lijun Rong,
    • a. Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China;
    • b. Qingdao Academy of Chinese Medicinal Sciences, Shandong University of Traditional Chinese Medicine, Qingdao, 266122, China;
    • c. College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China;
    • d. Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, 60612, USA

    Abstract: Influenza A virus (IAV) genome comprises eight negative-sense RNA segments, of which the replication is well orchestrated and the delicate balance of multiple segments are dynamically regulated throughout IAV life cycle. However, previous studies seldom discuss these balances except for functional hemagglutinin-neuraminidase balance that is pivotal for both virus entry and release. Therefore, we attempt to revisit IAV life cycle by highlighting the critical role of "genome balance". Moreover, we raise a "balance regression" model of IAV evolution that the virus evolves to rebalance its genome after reassortment or interspecies transmission, and direct a "balance compensation" strategy to rectify the "genome imbalance" as a result of artificial modifications during creation of recombinant IAVs. This review not only improves our understanding of IAV life cycle, but also facilitates both basic and applied research of IAV in future.

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