Citation: Mengying Liang, Wanbo Tai, Yunyun Wang, Yulong Dai, Yanfeng Yao, Juan Min, Yiwu Zhou, Liang Liu, Chao Shan, Han Xia, Zhiming Yuan. SARS-CoV-2 infection induces testicular injury in Rhesus macaque .VIROLOGICA SINICA, 2022, 37(6) : 934-937.  http://dx.doi.org/10.1016/j.virs.2022.10.008

SARS-CoV-2 infection induces testicular injury in Rhesus macaque

  • Corresponding author: Han Xia, hanxia@wh.iov.cn
    Zhiming Yuan, yzm@wh.iov.cn
  • Received Date: 24 May 2022
    Accepted Date: 21 October 2022
    Available online: 28 October 2022
  • Highlights
    1 The infection of SARS-CoV-2 lead to varying degrees of testicular pathological damage.
    2 The NP antigen of SARS-CoV-2 was not found in male reproductive system of rhesus macaque.
    3 Infection-associated inflammatory insult and sex hormone fluctuations may account for the testicular pathophysiology.

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  • 10.1016j.virs.2022.10.008-ESM.doc
    1. Abdel-Moneim, A.S., Abdelwhab, E.M., 2020. Evidence for SARS-CoV-2 infection of animal hosts. Pathogens 9, 529.

    2. Enikeev, D., Taratkin, M., Morozov, A., Petov, V., Korolev, D., Shpikina, A., Spivak, L., Kharlamova, S., Shchedrina, I., Mestnikov, O., Fiev, D., Ganzha, T., Geladze, M., Mambetova, A., Kogan, E., Zharkov, N., Demyashkin, G., Shariat, S.F., Glybochko, P., 2022. Prospective two-arm study of the testicular function in patients with COVID-19. Andrology 10, 1047–1056.

    3. China Medical Treatment Expert Group For, C Guan, W.J., Ni, Z.Y., Hu, Y., Liang, W.H., Ou, C.Q., He, J.X., Liu, L., Shan, H., Lei, C.L., Hui, D.S.C., Du, B., Li, L.J., Zeng, G., Yuen, K.Y., Chen, R.C., Tang, C.L., Wang, T., Chen, P.Y., Xiang, J., Li, S.Y., Wang, J.L., Liang, Z.J., Peng, Y.X., Wei, L., Liu, Y., Hu, Y.H., Peng, P., Wang, J.M., Liu, J.Y., Chen, Z., Li, G., Zheng, Z.J., Qiu, S.Q., Luo, J., Ye, C.J., Zhu, S.Y., Zhong, N.S., 2020. Clinical characteristics of coronavirus disease 2019 in China. N. Engl. J. Med. 382, 1708–1720.

    4. Kotb, M.A., El Henawy, A., Talaat, S., Aziz, M., El Tagy, G.H., El Barbary, M.M., Mostafa, W., 2005. Immune-mediated liver injury: prognostic value of CD4+, CD8+, and CD68+ in infants with extrahepatic biliary atresia. J. Pediatr. Surg. 40, 1252–1257.

    5. Le Tortorec, A., Matusali, G., Mahe, D., Aubry, F., Mazaud-Guittot, S., Houzet, L., DejucqRainsford, N., 2020. From ancient to emerging infections: the odyssey of viruses in the male genital tract. Physiol. Rev. 100, 1349–1414.

    6. Li, M.Y., Li, L., Zhang, Y., Wang, X.S., 2020. Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues. Infect Dis Poverty 9, 45.

    7. Ma, L., Xie, W., Li, D., Shi, L., Ye, G., Mao, Y., Xiong, Y., Sun, H., Zheng, F., Chen, Z., Qin, J., Lyu, J., Zhang, Y., Zhang, M., 2021. Evaluation of sex-related hormones and semen characteristics in reproductive-aged male COVID-19 patients. J. Med. Virol. 93, 456–462.

    8. Madjunkov, M., Dviri, M., Librach, C., 2020. A comprehensive review of the impact of COVID-19 on human reproductive biology, assisted reproduction care and pregnancy:a Canadian perspective. J. Ovarian Res. 13, 140.

    9. Qiao, Y., Wang, X.M., Mannan, R., Pitchiaya, S., Zhang, Y., Wotring, J.W., Xiao, L., Robinson, D.R., Wu, Y.M., Tien, J.C., Cao, X., Simko, S.A., Apel, I.J., Bawa, P., Kregel, S., Narayanan, S.P., Raskind, G., Ellison, S.J., Parolia, A., Zelenka-Wang, S., Mcmurry, L., Su, F., Wang, R., Cheng, Y., Delekta, A.D., Mei, Z., Pretto, C.D., Wang, S., Mehra, R., Sexton, J.Z., Chinnaiyan, A.M., 2020. Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2. Proc. Natl. Acad. Sci. U. S. A. 118, e2021450118.

    10. Shan, C., Yao, Y.F., Yang, X.L., Zhou, Y.W., Gao, G., Peng, Y., Yang, L., Hu, X., Xiong, J., Jiang, R.D., Zhang, H.J., Gao, X.X., Peng, C., Min, J., Chen, Y., Si, H.R., Wu, J., Zhou, P., Wang, Y.Y., Wei, H.P., Pang, W., Hu, Z.F., Lv, L.B., Zheng, Y.T., Shi, Z.L., Yuan, Z.M., 2020. Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques. Cell Res. 30, 670–677.

    11. Takahashi, T., Ellingson, M.K., Wong, P., Israelow, B., Lucas, C., Klein, J., Silva, J., Mao, T., Oh, J.E., Tokuyama, M., Lu, P., Venkataraman, A., Park, A., Liu, F., Meir, A., Sun, J., Wang, E.Y., Casanovas-Massana, A., Wyllie, A.L., Vogels, C.B.F., Earnest, R., Lapidus, S., Ott, I.M., Moore, A.J., Yale, I.R.T., Shaw, A., Fournier, J.B., Odio, C.D., Farhadian, S., Dela Cruz, C., Grubaugh, N.D., Schulz, W.L., Ring, A.M., Ko, A.I., Omer, S.B., Iwasaki, A., 2020. Sex differences in immune responses that underlie COVID-19 disease outcomes. Nature 588, 315–320.

    12. Tian, Y., Zhou, L.Q., 2021. Evaluating the impact of COVID-19 on male reproduction. Reproduction 161, R37–R44.

    13. Xu, J., Qi, L., Chi, X., Yang, J., Wei, X., Gong, E., Peh, S., Gu, J., 2006. Orchitis: a complication of severe acute respiratory syndrome (SARS). Biol. Reprod. 74, 410–416.

    14. Yang, M., Chen, S., Huang, B., Zhong, J.M., Su, H., Chen, Y.J., Cao, Q., Ma, L., He, J., Li, X.F., Li, X., Zhou, J.J., Fan, J., Luo, D.J., Chang, X.N., Arkun, K., Zhou, M., Nie, X., 2020. Pathological findings in the testes of COVID-19 patients: clinical implications. Eur Urol Focus 6, 1124–1129.

    15. Zhou, P., Yang, X.L., Wang, X.G., Hu, B., Zhang, L., Zhang, W., Si, H.R., Zhu, Y., Li, B., Huang, C.L., Chen, H.D., Chen, J., Luo, Y., Guo, H., Jiang, R.D., Liu, M.Q., Chen, Y., Shen, X.R., Wang, X., Zheng, X.S., Zhao, K., Chen, Q.J., Deng, F., Liu, L.L., Yan, B., Zhan, F.X., Wang, Y.Y., Xiao, G.F., Shi, Z.L., 2020. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 579, 270–273.

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    SARS-CoV-2 infection induces testicular injury in Rhesus macaque

      Corresponding author: Han Xia, hanxia@wh.iov.cn
      Corresponding author: Zhiming Yuan, yzm@wh.iov.cn
    • a Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430061, China;

    Abstract: Highlights
    1 The infection of SARS-CoV-2 lead to varying degrees of testicular pathological damage.
    2 The NP antigen of SARS-CoV-2 was not found in male reproductive system of rhesus macaque.
    3 Infection-associated inflammatory insult and sex hormone fluctuations may account for the testicular pathophysiology.

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