Case study: May human norovirus infection be associated with premature delivery?

Jiaying Cao; Yuetong Li; Feiyang Xue; Ziyang Sheng; Libo Liu; Yingying Zhang; Lele Wang; Liang Zeng; Yanmin Jiang; Dongying Fan; Fang Li; Jing An

doi:10.1016/j.virs.2024.10.004

December 2024

Citation: Jiaying Cao, Yuetong Li, Feiyang Xue, Ziyang Sheng, Libo Liu, Yingying Zhang, Lele Wang, Liang Zeng, Yanmin Jiang, Dongying Fan, Fang Li, Jing An. Case study: May human norovirus infection be associated with premature delivery? .VIROLOGICA SINICA, 2024, 39(6) : 951-962. http://dx.doi.org/10.1016/j.virs.2024.10.004

Case study: May human norovirus infection be associated with premature delivery?

Jiaying Cao ^a,b ,
Yuetong Li ^a ,
Feiyang Xue ^a ,
Ziyang Sheng ^a ,
Libo Liu ^a ,
Yingying Zhang ^a,c ,
Lele Wang ^d ,
Liang Zeng ^e ,
Yanmin Jiang ^c ,
Dongying Fan ^a ,
Fang Li ^{d
,,} ,
Jing An ^{a
,,}

cstr: 32224.14.j.virs.2024.10.004

a. Department of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China;
b. Department of Clinical Laboratory, The Fifth People's Hospital of Jinan, Jinan, 250022, China;
c. Department of Blood Transfusion, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China;
d. Department of Obstetrics & Gynaecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510180, China;
e. Department of Pathology, Guangzhou Women and Children Medical Center, Guangzhou Medical University, Guangzhou, 510180, China

Corresponding author: Fang Li, gz8hlf@126.com
Jing An, anjing@ccmu.edu.cn
Received Date: 06 February 2024
Accepted Date: 18 October 2024
Available online: 28 October 2024

Abstract

Human norovirus (HuNoV) is the leading cause of acute gastroenteritis. The varying severity of chronic infection in patients with underlying immune deficiencies poses additional burdens on public health. However, the potential effects of HuNoV infection during pregnancy, a specific immune perturbed state, have been rarely reported. Recently, four cases of HuNoV-infected patients in the late stages of pregnancy were admitted to the Guangzhou Women and Children's Medical Center, and premature rupture of membranes as primary adverse outcome was observed in these cases. Samples of fetal accessory tissue were collected from two of these cases at delivery to explore the potential pathogenesis. Pathological analysis showed placental malperfusion in both maternal and fetal vascular, while a decrease in vessels was not observed in villi of placenta. There was obvious pathological change in the chorion of fetal membrane, accompanied by a tendency of Th-1 immune bias. Notably, aggregation of M2 macrophages was observed in the chorion of the fetal membrane, potentially recruited for tissue repair. Next-generation sequencing showed minimal changes in immune pathways within placenta tissue. A gene panel associated with immunosuppression was identified in the fetal membrane of HuNoV-infected women compared to those of normal parturient. Taken together, this study provides clues for the association between the HuNoV and premature delivery, which requires the attention of the clinicians.
- Human norovirus (HuNoV)
- , Adverse pregnancy outcome
- , Premature delivery
- , Premature rupture of membranes
- , Virus infection

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