Citation: Fan Zhang, Jianbo Xia, Ling Wang. The effectiveness of two doses of Hecolin vaccine in response to outbreaks in resource-limited settings .VIROLOGICA SINICA, 2025, 40(6) : 1058-1060.  http://dx.doi.org/10.1016/j.virs.2025.11.001

The effectiveness of two doses of Hecolin vaccine in response to outbreaks in resource-limited settings

  • Corresponding author: Fan Zhang, zhangfanmd@bjmu.edu.cn
  • Received Date: 15 July 2025
    Accepted Date: 07 November 2025
    Available online: 11 November 2025
  • Highlights
    1. The use of Hecolin vaccine with a 2-dose schedule can replace the 3-dose schedule during campaigns in HEV outbreak settings.
    2. Vaccination against hepatitis E during pregnancy may be feasible.
    3. A single dose of the vaccine may not provide full protection.

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    1. Devarbhavi, H., Asrani, S. K., Arab, J. P., Nartey, Y. A., Pose, E. & Kamath, P. S. 2023. Global burden of liver disease: 2023 update. J Hepatol, 79, 516-537.

    2. Nesbitt, R. C., Azman, A. S., Asilaza, V. K., Edwards, J. K., Gitahi, P., Nkemenang, P., Duncker, J., Haile, M., Gakima, P., Wamala, J. F., Loro, F. B., Biem, D., Staderini, N., Albela, M., Rull, M., Rumunu, J., Ciglenecki, I. & Gignoux, E. 2024. Safety of hepatitis E vaccine in pregnancy: an emulated target trial following a mass reactive vaccination campaign in Bentiu internally displaced persons camp, South Sudan. Lancet Glob Health, 12, e1881-e1890.

    3. Nesbitt, R. C., Kinya asilaza, V., Alvarez, C., Gitahi, P., Nkemenang, P., Duncker, J., Haile, M., Gakima, P., Wamala, J. F., Loro, F. B., Koyuncu, A., Biem, D., Albela, M., Rull, M., Gignoux, E., Rumunu, J., Eckerle, I., Ciglenecki, I. & Azman, A. S. 2025. The effectiveness of two doses of recombinant hepatitis E vaccine in response to an outbreak in Bentiu, South Sudan: a case-control and bias indicator study. Lancet Infect Dis, 25, 537-547.

    4. Peron, J. M., Larrue, H., Izopet, J. & Buti, M. 2023. The pressing need for a global HEV vaccine. J Hepatol, 79, 876-880.

    5. WHO. Highlights from the Meeting of the Strategic Advisory Group of Experts (SAGE) on Immunization, March 11-13, 2024, https://www.who.int/publications/m/item/highlights-from-the-meeting-of-thestrategic-advisory-group-of-experts-(sage)-on-immunization-11-13-march-2024.

    6. Zhang, F., Shi, Z., Wu, Y., Xia, J. & Wang, L. 2025. Immunogenicity and Efficacy of an Accelerated Vaccination Schedule Against Hepatitis E Virus Infection in Rabbits. J Med Virol, 97, e70218.

    7. Zhang, F., Wang, J., Cheng, J., Zhang, X., He, Q., Zhaochao, L., Shu, J., Yan, L., WANG, L., WANG, L. & ZHANG, J. 2022. Clinical features of sporadic hepatitis E virus infection in pregnant women in Shanghai, China. J Infect, 84, 64-70.

    8. Zhang, F., Yang, Z., Dai, C., He, Q., Liang, Z., Liu, T., Huang, W., Wang, Y., Wang, L. & WANG, L. 2023. Efficacy of an accelerated vaccination schedule against hepatitis E virus infection in pregnant rabbits. J Med Virol, 95, e28193.

    9. Zhang, Y., Zeng, H., Liu, P., Liu, L., Xia, J., Wang, L., Zou, Q., Wang, L. & Zhuang, H. 2015. Hepatitis E vaccine immunization for rabbits to prevent animal HEV infection and zoonotic transmission. Vaccine, 33, 4922-4928.

    10. Zhu, F. C., Zhang, J., Zhang, X. F., Zhou, C., Wang, Z. Z., Huang, S. J., Wang, H., Yang, C. L., Jiang, H. M., Cai, J. P., Wang, Y. J., Ai, X., Hu, Y. M., Tang, Q., Yao, X., Yan, Q., Xian, Y. L., Wu, T., Li, Y. M., Miao, J., Ng, M. H., Shih, J. W. & Xia, N. S. 2010. Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial. Lancet, 376, 895-902.

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    The effectiveness of two doses of Hecolin vaccine in response to outbreaks in resource-limited settings

      Corresponding author: Fan Zhang, zhangfanmd@bjmu.edu.cn
    • a. Department of Clinical Laboratory Medicine, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430070, China;
    • b. Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China

    Abstract: Highlights
    1. The use of Hecolin vaccine with a 2-dose schedule can replace the 3-dose schedule during campaigns in HEV outbreak settings.
    2. Vaccination against hepatitis E during pregnancy may be feasible.
    3. A single dose of the vaccine may not provide full protection.

    Figure (1)  Reference (10) Relative (20)

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