Study of Biological Properties of Cell Lines Transformed by Herpes Simplex Virus
Abstract: The biological properties of three cell lines transformed by HSV-2 were investigated. The results indicate that the transformed cell lines possess the following characteristies:(1) chromosomal abnormalities; (2) reduce of requirement for serum factor; (3) rapid growth; (4) colony formation in soft agar; (5) increase of agglutination by Con Aand(6) induction of malignant tumor in nude mice These strongly suggest that the transformed cells are neoplastic.