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Citation: TANG Hua, LIN Zhong-Yuan. Assay for HSV-Induced Deoxythymidine Kinase and Its Application to Antiviral Compound Study [J].VIROLOGICA SINICA, 1988, 3(2) : 148.

Assay for HSV-Induced Deoxythymidine Kinase and Its Application to Antiviral Compound Study

  • An assay for herpes simplex virus type 1 and 2 induced deoxythymidine (dTK) was described by using ~(125)Ⅰ-UdR as substrate. The assay was also used for detecting the sensitivity of HSV-1 and HSV-2 induced dTK to DHPG. The result showed that sensitivity of viral dTK to DHPG was higher than HeLa cell-dTK s. In addition, we thought that toxicity of DHPG to host cells might be related to the low sensitivity of cell-dTK to DHPG.

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    Assay for HSV-Induced Deoxythymidine Kinase and Its Application to Antiviral Compound Study

    • 1. Department of Microbiology
    • 2. Tianjin Medical College

    Abstract: An assay for herpes simplex virus type 1 and 2 induced deoxythymidine (dTK) was described by using ~(125)Ⅰ-UdR as substrate. The assay was also used for detecting the sensitivity of HSV-1 and HSV-2 induced dTK to DHPG. The result showed that sensitivity of viral dTK to DHPG was higher than HeLa cell-dTK s. In addition, we thought that toxicity of DHPG to host cells might be related to the low sensitivity of cell-dTK to DHPG.

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