In Vitro Induction of SRBC-sgecific Antihody by Human Tonsillar Lymphocytes and the Effects of HSV-1 Infection on it

We established a stable human tonsillar cell culture-immunization systemin vitro, in which sheep red blood cells (SRBC), a virus-irrelevant antigen,induced efficiently specific antibody production. In contrast to traditional con-cepts, we demonstrated that adhering cells (mainly macrophages) in tonsilsplayed a suppressive role in induction of specific antibody response in vitro.Depletion of adhering cells increased significantly the production of this anti-body. We also found the SRBC co-stimulated with sui...