Pathogenicity of Epidemic Hemorrhagic Fever Virus in Suckling Mice
Abstract: It was observed that two strains EHF virus which were isolated newly from patients had pathogenicity on suckling mice.The EHF virus particles were found in the infected mice brain under electron microscope.On IF examination viral antigen could be found in brain, lungs, liver, kidneys and other organs.Comparing intracerebral with intrapertoneal inoculation, it was found that there is no appaerent difference in viral antigen distribution.But the infectious virus titre of brain in the former was one logarithm ...