The Safety Evaluation of Several Tea Pests NPV in Mice by Micronucleus Assay

A rapid method, micronucleus assay which proposed in the scoring of chromosomal aberrations has been dealt with the safety evaluation of insect viruses of tea pests(Biston marginata NPV, Euproctis pseudoconspersa NPV and Buzura suppressaria NPV)in mice. By scoring the frequency of micronuclei in the bone marrow cells of mice, we found that less than 0.3% of micronucleus in virion suspensions and polyhedra infections,regardless of either single or mixed viruses. It was shown that cyclophosphamidum infection ...