Citation: SHU Yong-Xin, LIU Wen-Xue, NIE Zi-Lin. Neutralizing Antibody Responses in Human Immunized with M. Gerbil Kidney Tissue Culture Inactivated HFRS Vaccine Assessed by Two Methods .VIROLOGICA SINICA, 1992, 7(2) : 176.

Neutralizing Antibody Responses in Human Immunized with M. Gerbil Kidney Tissue Culture Inactivated HFRS Vaccine Assessed by Two Methods

  • Available online: 05 June 1992
  • In this study, expanded human trial with M, Gerbil kidney tissue culture inactivated HFRS vaccine was carried out and neutralizing antibody response was assessed by plaque reduction neutralization(PRNT) and CPE neutralization(CPENT) methods. According to the data of all 74 person immune sera assayed by the two methods, the rates of seroconversion and GMT tesed by CPENT were significantly higher than that by PRNT. Several vaccinating groups were studied and the neutralizing antibody levels were as follows: v...

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    Neutralizing Antibody Responses in Human Immunized with M. Gerbil Kidney Tissue Culture Inactivated HFRS Vaccine Assessed by Two Methods

    • 1. National Institute for the Contrl of Pharmacenlical & Biological Products
    • 2. Beijing 100050

    Abstract: In this study, expanded human trial with M, Gerbil kidney tissue culture inactivated HFRS vaccine was carried out and neutralizing antibody response was assessed by plaque reduction neutralization(PRNT) and CPE neutralization(CPENT) methods. According to the data of all 74 person immune sera assayed by the two methods, the rates of seroconversion and GMT tesed by CPENT were significantly higher than that by PRNT. Several vaccinating groups were studied and the neutralizing antibody levels were as follows: v...

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