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Volume 08 Issue 3
June 1993
    Citation: TANG Yong-Ming, YANG Wei-Song, HONG Tao, ZHOU Jing-Yi. Experimental Infection of Hemorrhagic Fever with Renal Syndrome Virus in Mice and Viral Antigen Localization in Mouse Lymphocyte Subpopulations .VIROLOGICA SINICA, 1993, 8(3) : 218-225.
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    Experimental Infection of Hemorrhagic Fever with Renal Syndrome Virus in Mice and Viral Antigen Localization in Mouse Lymphocyte Subpopulations

    • 1.

      Department of Infectious Diseases

    • 2.

      Tangdu Hospital

    • 3.

      The Fourth Military Meical University

    • Available online: 05 September 1993
    • Double-immunoctytochemistry and double-immunoelectron microscopy were applied to investigate the pathogenesis and virus localization in cyclophosphamide-treated adult and suckling BALB/c mice af- ter the infection of hemorrhagic fever with renal syndrome virus. It was found that, after the infec tion, immunologically immature or deficient mice developed disease and died regularly, while normal adult mice showed only a subelinical infection. The major difference of virus localization between the diseased and...
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      Experimental Infection of Hemorrhagic Fever with Renal Syndrome Virus in Mice and Viral Antigen Localization in Mouse Lymphocyte Subpopulations

      • 1. Department of Infectious Diseases
      • 2. Tangdu Hospital
      • 3. The Fourth Military Meical University

      Abstract: Double-immunoctytochemistry and double-immunoelectron microscopy were applied to investigate the pathogenesis and virus localization in cyclophosphamide-treated adult and suckling BALB/c mice af- ter the infection of hemorrhagic fever with renal syndrome virus. It was found that, after the infec tion, immunologically immature or deficient mice developed disease and died regularly, while normal adult mice showed only a subelinical infection. The major difference of virus localization between the diseased and...

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