Citation: GUO Guang-Song, XIAO Hong, CHENG Li, WEN Li, YANG Zhan-Qiu. Observation of Pathological and Viral Antigen of Epidemic-Hemorrhagic Fever Virus Infection in Suckling Mice .VIROLOGICA SINICA, 1994, 9(1) : 81.

Observation of Pathological and Viral Antigen of Epidemic-Hemorrhagic Fever Virus Infection in Suckling Mice

  • Available online: 05 March 1994
  • Epidemic hemorrhagic fever virus origined from patients with epidemic hemorrhagic fever was inoculated into suckling mice,The results showed that the suckling mice died regularly,The viral antigenand pathological damage appeared in the brain,lung,liver and kidney,The characterization of patho-logical changes were congestion, hemorrhage and degeneration of blood vessels.The viral perticles canbe found in hippocampus region,The viral antigen can be detected in cytoplasm.The resultS suggestthat suckling mice were susceptible for human original epidemic hemorrhagic fever virus.

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    Observation of Pathological and Viral Antigen of Epidemic-Hemorrhagic Fever Virus Infection in Suckling Mice

    • 1. Hubei Medical University

    Abstract: Epidemic hemorrhagic fever virus origined from patients with epidemic hemorrhagic fever was inoculated into suckling mice,The results showed that the suckling mice died regularly,The viral antigenand pathological damage appeared in the brain,lung,liver and kidney,The characterization of patho-logical changes were congestion, hemorrhage and degeneration of blood vessels.The viral perticles canbe found in hippocampus region,The viral antigen can be detected in cytoplasm.The resultS suggestthat suckling mice were susceptible for human original epidemic hemorrhagic fever virus.

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