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Volume 11 Issue 4
August 1996
    Citation: XIAO Hong, YANG Zhan-Qiu, WEN Li, LIU Yan-Wen. Pharm acodynam ics Studies of Alternanthera philoxeroides Griseb in Oral for EHFV Infection in Suckling Mice .VIROLOGICA SINICA, 1996, 11(4) : 348.
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    Pharm acodynam ics Studies of Alternanthera philoxeroides Griseb in Oral for EHFV Infection in Suckling Mice

    • 1.

      Virus Research Institute，Hubei Medical University，Wuhan 430071Hubei Traditional Medical College．Wuhan 430060

    • Available online: 05 December 1996
    • Antiviral effect of Alternanthera philoxeroides Griseb(APG)was studied in oral for epi-demic hemorrhagic fever virus(EHFV)infection in suckling mice.The APG dosages of A,BandC groups were 5mg/(g·d),7.5mg/(g·d)and 10mg/(g·d),respectively. The results showedthat the survival rate of A,B and C group were 80.0%,72.2% and 40.0%,the means time day(MTD)were 56.5±0.9, 53.5±1.1 and 41.5±2.7 day,respectively.The survival rate and MTD were 0.0% and 26.3±0.8 day in untreated viral control group.The antiviral effect of theAPG was similar with the ribavirin.This indicated that the APG was effective in treatment of epidemic hemorrhagic fever.
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      Pharm acodynam ics Studies of Alternanthera philoxeroides Griseb in Oral for EHFV Infection in Suckling Mice

      • 1. Virus Research Institute，Hubei Medical University，Wuhan 430071Hubei Traditional Medical College．Wuhan 430060

      Abstract: Antiviral effect of Alternanthera philoxeroides Griseb(APG)was studied in oral for epi-demic hemorrhagic fever virus(EHFV)infection in suckling mice.The APG dosages of A,BandC groups were 5mg/(g·d),7.5mg/(g·d)and 10mg/(g·d),respectively. The results showedthat the survival rate of A,B and C group were 80.0%,72.2% and 40.0%,the means time day(MTD)were 56.5±0.9, 53.5±1.1 and 41.5±2.7 day,respectively.The survival rate and MTD were 0.0% and 26.3±0.8 day in untreated viral control group.The antiviral effect of theAPG was similar with the ribavirin.This indicated that the APG was effective in treatment of epidemic hemorrhagic fever.

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