Human Herpesvirus 7 Induces Tumor Necrosis Factor Alpha in Umbilical Cord Blood M ononuclear Cell Cultures
Abstract: The production of tumor necrosis factor alpha(TNF-a)induced by human herpesvims 7(HHV一7)G1asgow strain and Nanjing loca1 strain YY5 and HHV一6 GS strain in umbilica1 cord and pheripheraI blood mononuclear cells cultures was studied by means of biologicaI activity assay. It was observed that HHV.7 is another strong inducer of TNF.q. HHV.7.infected cultlJre~ reached the maximal1eveI of TNF.q at 3 to 4 days postinfetion。which is later than that of HHv_ 6(2 days postinfection).Compared with HHv.6,the amounts of TNF.a in HHV一7一infected cul tures are smaller at 24 h postinfetion(P0.05),but the amounts of them are alI higher than that of uninfected cells(P0.05),and there is no diference between G1asgow and YY5 strain (P0.05).These results indicated that HHV一6 and HHV一7 can exert immunomodulatory by stimulating the CBMCs to produce TNF-a。