Study on Indeterminate HBsAg Samples
Abstract: Thirteen indeterminate HBsAg samples were tested with 21 sorts of HBsAg kits, anti HBs and anti HBc kits. HBV DNA was detected with nested PCR. The results showed that all of HBsAg kits can not easily detected HBsAg from some HBV DNA positive samples. It indicated that HBsAg concentration may be lower or HBV may be S mutants in those samples. So it is necessary to improve the sensitivity of HBsAg and to develop the diagnostic kit to detect HBV S mutants.