Citation: LIN Jing-Xiang, WANG You-Chun, ZHANG Hua-Yuan. Study on Indeterminate HBsAg Samples .VIROLOGICA SINICA, 2000, 15(1) : 8-10.

Study on Indeterminate HBsAg Samples

  • Available online: 05 March 2000
  • Thirteen indeterminate HBsAg samples were tested with 21 sorts of HBsAg kits, anti HBs and anti HBc kits. HBV DNA was detected with nested PCR. The results showed that all of HBsAg kits can not easily detected HBsAg from some HBV DNA positive samples. It indicated that HBsAg concentration may be lower or HBV may be S mutants in those samples. So it is necessary to improve the sensitivity of HBsAg and to develop the diagnostic kit to detect HBV S mutants.

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    Study on Indeterminate HBsAg Samples

    • 1. Dept of Hepatitis,National Institute 

    Abstract: Thirteen indeterminate HBsAg samples were tested with 21 sorts of HBsAg kits, anti HBs and anti HBc kits. HBV DNA was detected with nested PCR. The results showed that all of HBsAg kits can not easily detected HBsAg from some HBV DNA positive samples. It indicated that HBsAg concentration may be lower or HBV may be S mutants in those samples. So it is necessary to improve the sensitivity of HBsAg and to develop the diagnostic kit to detect HBV S mutants.

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