Genotyping and Sequencing analysis of 15 strains of TT Virus from Chinese isolates

Recently, a novel virus named TT Virus has been identified in serum from patients with elevated ALT levels and others. TTV was detected by PCR using a set of primers from conserved region in the TTV genome. cloning and sequencing of the amplifications in 15 cases of Chinese blood donors and dialysis patients were carrited out. Sequence comparison within 271 base pairs in the region between positions 1915 and 2185 showed homology rates varying from 66.8% to 99.3% among 15 Chinese isolates, and from 66.1% to 97.4% between Chinese strains and TTV isolates from Japanese isolates sequenced. This result suggests that a new sub genotype existes in Chinese TTV isolates.