Preliminary Study on the Activation of TRAFs M ediated by Epstein-Barr Virus Encoded LM P1 in Nasopharyngeal Carcinoma

The present is aimed at identifying the activation of TRAFs in nasopharyngeal carcinoma (NPC)ill"oitro The differentia1 expression of TRAF2、TRAF3 was not detected in RNA and protein 1evel，whereas the expression of TRAF1 in HNE2一LM P1 eel1 1ines was much more abundant than that in HNE2 cell lines， suggesting that TRAF1 niay be an inducible molecule： More importantly． TRAF1，TRAF2 or TRAF3 were activated in the HNE2一LMP1 cells，whereas TRAF1，TRAF2 or TRAF3 were not activated in HNE2 cells as detected by the immunoprecipitation-W estern blotting as— say These data provide an experimental basis for our study beginning from the signal transducation pathway for the eluccidation of the mechanism of LM P1 carcinogenesis in NPC