Citation: SHEN Yuan—ying, YANG Zhanqiu, LIU Jian.iun . al, . Study of Rheum officinale Against Coxsackievirus B3 in vivo .VIROLOGICA SINICA, 2001, 16(1) : 85-87.

Study of Rheum officinale Against Coxsackievirus B3 in vivo

  • Available online: 05 February 2001
  • In order to search a effective therapy for viral myocardifis,antivial activity of Rheum offici— hale on Coxsackieivirus B3(CVB3)was evaluated in BALB/C mice.After being determined optium scheme with orthogonal design,mice infected with CVB3 were treated with Rheum officinale.rib— avirin and 0.9% NaC1 The survival rates of the mice were 35% ,5% and 5% ;M ed Jan survival time were 23.11 and 10.5 days;Infectious viml titers repecfively,The lesions of cardiac tissues lightened were 10一 ,10一 ’and 10一 ’TCID50/0.1 mL inmicetreated withRheum offinicale.These re— suits showed that Rheum officinale was effective in treatment of CVB3 infected mice The study pro— vided scientific basis for further research and widen antiviral spectrum of Rheum officinale

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    Study of Rheum officinale Against Coxsackievirus B3 in vivo

    • 1. I Dep:lrtmerit ofMA’robiology.DaLi Medical college.Dali 671000,China

    Abstract: In order to search a effective therapy for viral myocardifis,antivial activity of Rheum offici— hale on Coxsackieivirus B3(CVB3)was evaluated in BALB/C mice.After being determined optium scheme with orthogonal design,mice infected with CVB3 were treated with Rheum officinale.rib— avirin and 0.9% NaC1 The survival rates of the mice were 35% ,5% and 5% ;M ed Jan survival time were 23.11 and 10.5 days;Infectious viml titers repecfively,The lesions of cardiac tissues lightened were 10一 ,10一 ’and 10一 ’TCID50/0.1 mL inmicetreated withRheum offinicale.These re— suits showed that Rheum officinale was effective in treatment of CVB3 infected mice The study pro— vided scientific basis for further research and widen antiviral spectrum of Rheum officinale

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