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Volume 17 Issue 2
April 2002
    Citation: W ANG Jlong．LIU Long—Ding, SUN M ing, DONG Cheng-Hong, WANG Li—Chun, WANG Jing-Jing．LI Qi—han, . Cloning and Analyzing a New PEBP Like Protein Gene in Human Fibroblast Cell Infected by HSV I .VIROLOGICA SINICA, 2002, 17(2) : 97-101.
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    Cloning and Analyzing a New PEBP Like Protein Gene in Human Fibroblast Cell Infected by HSV I

    • 1.

      Department of Viral and Immunology，Institute of medical Bio1~gy，CAMS and PUMC，Kunmlng 650118，China

    • Available online: 05 April 2002
    • In our study on the gene response to virus infection，a colony of 705bp—HSP一714 was se— lected from the cell specific cDNA library induced by HSVI infection．The gene sequence analysis re· vealed that it was a new complete gene sequence(Gene Bank Accession number~AF372624)with a complete ORF encoding 126 amino acids．The biological informatics aiualysis demonstrated that this pmtein contained a phosphatidylethanolamine—binding protein(PEBP)like domain，which had a high homology to the CEN—like family of plant and mam malian ete．genome．Furthermore，the evolution tree demonstrates that this gene shows more homologous to CEN—like family Of plant Therefore．it can be predicted that this gene might be a new member of human PEBP—like family with special significance
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      Cloning and Analyzing a New PEBP Like Protein Gene in Human Fibroblast Cell Infected by HSV I

      • 1. Department of Viral and Immunology，Institute of medical Bio1~gy，CAMS and PUMC，Kunmlng 650118，China

      Abstract: In our study on the gene response to virus infection，a colony of 705bp—HSP一714 was se— lected from the cell specific cDNA library induced by HSVI infection．The gene sequence analysis re· vealed that it was a new complete gene sequence(Gene Bank Accession number~AF372624)with a complete ORF encoding 126 amino acids．The biological informatics aiualysis demonstrated that this pmtein contained a phosphatidylethanolamine—binding protein(PEBP)like domain，which had a high homology to the CEN—like family of plant and mam malian ete．genome．Furthermore，the evolution tree demonstrates that this gene shows more homologous to CEN—like family Of plant Therefore．it can be predicted that this gene might be a new member of human PEBP—like family with special significance

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