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Volume 17 Issue 3
June 2002
    Citation: ZHONG Yan—wei, CHENG Jun, CHEN Xin—hua, WANG Gang, HONG Yuan, W ANG Lin, LI Li, ZHANG Ling—xia, CHEN Ju～mei. Epitope M apping of Hepatitis C Virus NS3 Antigen from a Phage Peptide Library by Using Imm obilized Specific M onocionai Antibody .VIROLOGICA SINICA, 2002, 17(3) : 202-205.
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    Epitope M apping of Hepatitis C Virus NS3 Antigen from a Phage Peptide Library by Using Imm obilized Specific M onocionai Antibody

    • 1.

      Gene Therapy Research Center，Institute of Infectious Diseseas ，Th 302 Hospital 0f PLA，Beijing 100039，China

    • Available online: 05 June 2002
    • Using HCV NS3 m onoclonal antibody as selective molecule， a 12 m ar phage peptide library was biopanned and positive clones were selected by ELISA ． com petition assay and DN A sequencing． Eleven positive clones were chosen for DN A sequencing．From the experim ent and sequencing com par— ison results，one epitope was confirm ed as m imotope of HCV N S3．HCV N S3 m im otope was obtained by phage peptide library screening．The result provides a new approach for HCV therapy and vaccine developm ent．
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      Epitope M apping of Hepatitis C Virus NS3 Antigen from a Phage Peptide Library by Using Imm obilized Specific M onocionai Antibody

      • 1. Gene Therapy Research Center，Institute of Infectious Diseseas ，Th 302 Hospital 0f PLA，Beijing 100039，China

      Abstract: Using HCV NS3 m onoclonal antibody as selective molecule， a 12 m ar phage peptide library was biopanned and positive clones were selected by ELISA ． com petition assay and DN A sequencing． Eleven positive clones were chosen for DN A sequencing．From the experim ent and sequencing com par— ison results，one epitope was confirm ed as m imotope of HCV N S3．HCV N S3 m im otope was obtained by phage peptide library screening．The result provides a new approach for HCV therapy and vaccine developm ent．

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