Citation: SONG Hong, FU Shi—hong, W ANG Huan—Yu, LIANG Guo—dong. The Relationships of Serotypes and Nucleotide Sequences 0f The Dengue viruses Genome .VIROLOGICA SINICA, 2002, 17(4) : 297-303.

The Relationships of Serotypes and Nucleotide Sequences 0f The Dengue viruses Genome

  • Available online: 05 November 2002
  • The aim of this study was to prove the relationships of serotypes and nucleotide sequences of the Dengue viruses genome.To this end,the nucleotide sequences of 5 noncoding region,3 一noncod— ing region,envelope E glycoprotein,nonstructural protein NS1 were aligned correspondingly.W ith four Dengue viruses phylogenetic groups which were correspo nding to four serotypes each other being identified,Our results demonstrate that there were no intergenomic recombination observed.The po s— sibility of intragenomic recombination and the similarity of nucleotide sequences of different Dengue viruses were analysed.

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    The Relationships of Serotypes and Nucleotide Sequences 0f The Dengue viruses Genome

    • 1. Institute of Virology,Chinese Academy of Preventive Medicine,Beijing 100052,China

    Abstract: The aim of this study was to prove the relationships of serotypes and nucleotide sequences of the Dengue viruses genome.To this end,the nucleotide sequences of 5 noncoding region,3 一noncod— ing region,envelope E glycoprotein,nonstructural protein NS1 were aligned correspondingly.W ith four Dengue viruses phylogenetic groups which were correspo nding to four serotypes each other being identified,Our results demonstrate that there were no intergenomic recombination observed.The po s— sibility of intragenomic recombination and the similarity of nucleotide sequences of different Dengue viruses were analysed.

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