p53 Expression and Genetic Evidence for Virus Infection in Cervical Carcinoma
Abstract: Abstract: Wle examined 121 Specimens of exfoliated cells and tissue of cervix for the presence of肿V一16/18 an d HSV一2 DNA by PCR.At the same time,we analysised 76 specimens from tissue ofcervix for the expression of p53 by immunohistochemical assay.The HPV一16/18 was found in 19(61.3%)of 31 cervical carcinoma,in 9(22.5%)of 40 chronic cervicitis,in 3(6.O%)of 50 normaluterine cervix.The positive rate of HSV一2 was 32.3% (10/31),2O.O% (8,4O)and 4.0% (2/50).1 emixed infection rate of肿V 16/18 an d HSV一2 was 16.1% in cervical carcinoma.The rates of positiveexpression ofp53 was found to have a gradient of crescendo in the tissues of chronic cervicitis.CIN an dcervical carcinoma.Wle found that cerv ical carcinoma is strongly related witll HPV一16/18 infection.Asynergetic action may OCCUr between HPv an d HSV一2 infections in the oncogenesis of cervicalcarcinoma.Th e overepression of p53 appears to be closely associated with the development of cervicalcan cer.Th ere is a matter ofclinical significan ce on the prevention an d treatment ofcervical carcinoma.