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Volume 18 Issue 4
August 2003
    Citation: YAN Yin, CHEN Xiao, YAN Yuan, fan g, YAN Xiao. Cytomegalovirus Infection Induces Variation of Cell Cycle and Cyclin E in M RC-5 cells .VIROLOGICA SINICA, 2003, 18(4) : 311-314.
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    Cytomegalovirus Infection Induces Variation of Cell Cycle and Cyclin E in M RC-5 cells

    • 1.

      The Institute of Virology of the Medical College of Wuhan University,Wuhan 430071，China

    • Available online: 05 August 2003
    • Abstract：In this Paper we repoaed that Cytomegalovirus infection induced high levels of Cyclin E， increases of Cyclin E／cdk2 activity，leading to cell cycle arrest．By 72h postinfection(at a multiplicity of infection of 1 0 PFU／per cel1)，29％ of the cells was S phase，69％ of the cells in Gz／M phase，only 2％ of the cells in Go／G1 phase by flow cytometry an alysis．By 20h postinfection，the levels of cyclinE in infected M RC．5 cells were eightfold greater than those in mock-infectcd cells by ELISA an alysis．The cyclin E／cdk2 kinase activities in HCM V-infected M RC一5 cells were relative to the levels of cyclinE essentially．
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      Cytomegalovirus Infection Induces Variation of Cell Cycle and Cyclin E in M RC-5 cells

      • 1. The Institute of Virology of the Medical College of Wuhan University,Wuhan 430071，China

      Abstract: Abstract：In this Paper we repoaed that Cytomegalovirus infection induced high levels of Cyclin E， increases of Cyclin E／cdk2 activity，leading to cell cycle arrest．By 72h postinfection(at a multiplicity of infection of 1 0 PFU／per cel1)，29％ of the cells was S phase，69％ of the cells in Gz／M phase，only 2％ of the cells in Go／G1 phase by flow cytometry an alysis．By 20h postinfection，the levels of cyclinE in infected M RC．5 cells were eightfold greater than those in mock-infectcd cells by ELISA an alysis．The cyclin E／cdk2 kinase activities in HCM V-infected M RC一5 cells were relative to the levels of cyclinE essentially．

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