Preliminary Study of Apoptosis of SP2／0 Cells Induced by Hantaan virus

Abstract：To study the apoptosis of malignant carcinoma cells induced by Hantaan virus．SP2／0 cells cultured in vitro were infected with Hantaan virus．Their apoptosis profiles were detected using Giem sa staining，flow cytometry and immunohistochemistry staining．Giemsa staining showed typical apoptotic changes in infected cells；Apoptosis peaks were detected by flow cytometry； Immunohistochemistry staining showed apparent increase of Fas and FasL expression in infected cells compared with norm al cells．Th e results suggest that Hantaan virus could induce SP2／0 cells in vitro to undergo apoptosis which might be associated with Fas an d FasL．