Citation: GAO Juan, YANG Shou-jing*, LIU Yan fang. Preliminary Study of Apoptosis of SP2/0 Cells Induced by Hantaan virus .VIROLOGICA SINICA, 2003, 18(4) : 315-317.

Preliminary Study of Apoptosis of SP2/0 Cells Induced by Hantaan virus

  • Available online: 05 August 2003
  • Abstract:To study the apoptosis of malignant carcinoma cells induced by Hantaan virus.SP2/0 cells cultured in vitro were infected with Hantaan virus.Their apoptosis profiles were detected using Giem sa staining,flow cytometry and immunohistochemistry staining.Giemsa staining showed typical apoptotic changes in infected cells;Apoptosis peaks were detected by flow cytometry; Immunohistochemistry staining showed apparent increase of Fas and FasL expression in infected cells compared with norm al cells.Th e results suggest that Hantaan virus could induce SP2/0 cells in vitro to undergo apoptosis which might be associated with Fas an d FasL.

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    Preliminary Study of Apoptosis of SP2/0 Cells Induced by Hantaan virus

    • 1. Department ofPathology,the Fouah Military Medical University,Xi’art,710032,China

    Abstract: Abstract:To study the apoptosis of malignant carcinoma cells induced by Hantaan virus.SP2/0 cells cultured in vitro were infected with Hantaan virus.Their apoptosis profiles were detected using Giem sa staining,flow cytometry and immunohistochemistry staining.Giemsa staining showed typical apoptotic changes in infected cells;Apoptosis peaks were detected by flow cytometry; Immunohistochemistry staining showed apparent increase of Fas and FasL expression in infected cells compared with norm al cells.Th e results suggest that Hantaan virus could induce SP2/0 cells in vitro to undergo apoptosis which might be associated with Fas an d FasL.

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