Citation: LIU Zhao, YANG Zhan, XIAO Hong, WEN Lil, WANG Zhen. Antiviral Activity of Algefacient and Anti-inflammatory Against Influenza Virus in vitro and in vivo .VIROLOGICA SINICA, 2003, 18(6) : 534-537.

Antiviral Activity of Algefacient and Anti-inflammatory Against Influenza Virus in vitro and in vivo

  • Available online: 25 December 2003
  • Abstract:To observe the antiviral activity of Algefacient and anti-inflammatory(AI)against influenza virus,cell culture technique was used in M DCK cells to get virus inhibitory rate an d virus tiler by MTT assay an d hemagglitination test.Influenza virus infection model was established in mice,to observe the protection efect to mi ce death ,the inhibitory efect to pulmonary index and pulmonary virus titer.The results showed that 160ug/mL Algefacient an d anti-inflammatory Can completely inhibit the proliferation of influenza virus in MDCK cel1.0.1 gg, 0.5g/kg.1.2g,/kg dosage med cme orally given for 5 days could significan tly decrease the mortality rate,prolong the living time of infec ted mi ce, decrease the pulmonary index and pulmonary virus hemagglitination titer(PO.oi).This efect is similar to that of virazole at the same dosage leve1.W e conclude that AI is an efective anti-influenz a virus.compound/n vitro and in vivo.

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    Antiviral Activity of Algefacient and Anti-inflammatory Against Influenza Virus in vitro and in vivo

    • 1. TheInstituteof~rology,theMedicalSchool,Wuhan University,Wuhan 430071,China
    • 2. GuilinSanjin Pharmaceutical Co.LTD,GuHin 541004.china

    Abstract: Abstract:To observe the antiviral activity of Algefacient and anti-inflammatory(AI)against influenza virus,cell culture technique was used in M DCK cells to get virus inhibitory rate an d virus tiler by MTT assay an d hemagglitination test.Influenza virus infection model was established in mice,to observe the protection efect to mi ce death ,the inhibitory efect to pulmonary index and pulmonary virus titer.The results showed that 160ug/mL Algefacient an d anti-inflammatory Can completely inhibit the proliferation of influenza virus in MDCK cel1.0.1 gg, 0.5g/kg.1.2g,/kg dosage med cme orally given for 5 days could significan tly decrease the mortality rate,prolong the living time of infec ted mi ce, decrease the pulmonary index and pulmonary virus hemagglitination titer(PO.oi).This efect is similar to that of virazole at the same dosage leve1.W e conclude that AI is an efective anti-influenz a virus.compound/n vitro and in vivo.

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