Inhibitory Effects of Different Selenium Sources on Porcine Parvovirus Infection in vitro

Inhibitory effects of sodium selenite, DL-selenomethionine and Kappa-selenocarrag-eenan on Porcine parvovirus (PPV) infection of the PK-15 cells were studied. The influences of reduced glutathione (GSH) and D-mannitol on antiviral effects of selenium were also carried out in PK-15 cells. The results showed that all of the three selenium sources have an inhibitory effect on the PPV replication in vitro. DL-selenomethionine had the highest inhibitory effect while Kap-pa-selenocarrageenan had the lowest, and the inhibition was concentration-dependent. The GSH and D-mannitol have the ability to increase the antiviral effects of selenium. The antiviral effect was enhanced with the addition of both GSH and D-mannitol.