Roles of ICAM-1 and it’s Receptors in HPAIV Pneumonia
Abstract: The intercellular adhension molecular-1（ICAM-1）and it’s its receptors in the mice’s lungs of HPAIV and control mice pneumonia were detected by using immunohistochemistry staining after infected mice with Highly pathogenic avian influenza virus (HPAIV). The expressive level of ICAM–1, and its receptors of CD11b and CD18 were first detected after 24 hours infection in bronchial alveolar epithelial cells, bronchopulmonary capillary endothelial cells, and iinfiltrativing lymphomonocyte and monocytes, and reached were the peaks 4 days after infection. The highest expression of ICAM-1 and its receptors were detected when infected with 100LD50/50 μL HPAIV. The change was confirmed by the method of ELASA. Our results indicate that ICAM-1 and its receptors have the high expression level in HPAIVP pneumonia, and may play an important roles in the pathogenesis.