Citation: LI Mei-rong, TANG Tai-shan, ZHANG Chang-yin, WANG Kai-min, LI Ming-jie, CHEN Jia-qiu, LU Cheng-ping. Immuuological Surey of Canine Distemper in Large Felids in Zoos .VIROLOGICA SINICA, 2006, 21(4) : 368-370.

Immuuological Surey of Canine Distemper in Large Felids in Zoos

  • Corresponding author: LU Cheng-ping, 
  • Available online: 20 July 2006
  • Large felids, such as tigers, lions and leopards are often infected with Canine Distemper (CD). Blood samples from pre-immune Amur tiger, African lion and lynx were collected and the antibody against CDV was measured by neutralization tests. The results showed that their CDV antibody level were all below 1:5. After inoculated with attenuated CD vaccine, the young animals produced antibody in 14 days but the antibody levels of the adults increased rapidly within two months and maintained at titer of 1: 64, then gradually dropped after 9 to 11 months. After booster immunizing, antibody level went up rapidly to≥1:112. The vaccination was safe to the animals. Achroia Indian tiger, however, could not produce CDV neutralizing antibody after vaccination.

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    Immuuological Surey of Canine Distemper in Large Felids in Zoos

      Corresponding author: LU Cheng-ping,
    • 1. 1.Nanjing Forest Zoo, Nanjing 210028, China
    • 2. Jiangsu Entry-Exit Inspection and Quarantine Bureau, Nanjing 210001, China
    • 3. Key Lab of Animal Disaese Diagnostic & Immunology, Ministry of Agriculture, Nanjing Agricultural University, Nanjing 210095, China

    Abstract: Large felids, such as tigers, lions and leopards are often infected with Canine Distemper (CD). Blood samples from pre-immune Amur tiger, African lion and lynx were collected and the antibody against CDV was measured by neutralization tests. The results showed that their CDV antibody level were all below 1:5. After inoculated with attenuated CD vaccine, the young animals produced antibody in 14 days but the antibody levels of the adults increased rapidly within two months and maintained at titer of 1: 64, then gradually dropped after 9 to 11 months. After booster immunizing, antibody level went up rapidly to≥1:112. The vaccination was safe to the animals. Achroia Indian tiger, however, could not produce CDV neutralizing antibody after vaccination.

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