Citation: JIANG Li #, LI Pin-Zhong #, DONG Cheng-Hong, LI Qi-Han. Functional Analysis of SR-15 Protein of Human Fibroblast Induced by HSVⅠInfection .VIROLOGICA SINICA, 2006, 21(6) : 546-550.

Functional Analysis of SR-15 Protein of Human Fibroblast Induced by HSVⅠInfection

  • Corresponding author: LI Qi-Han, 
  • Available online: 20 November 2006
  • The binding of HSVⅠ to receptors of human fibroblast initiates viral infection and induces the cells to express specific proteins. SR-15, one of these proteins, was identified to interact with certain zinc finger proteins containing KRAB domain through binding zinc finger domain in yeast trap system. This interaction impacts the transcriptional repression of ZNF268, which is one of this type of zinc finger proteins in cells.

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    Functional Analysis of SR-15 Protein of Human Fibroblast Induced by HSVⅠInfection

      Corresponding author: LI Qi-Han,
    • 1. Institute of Medical Biology, Chinese Academy of Medical Science /Peking Union Medical College, Kunming 650118, China

    Abstract: The binding of HSVⅠ to receptors of human fibroblast initiates viral infection and induces the cells to express specific proteins. SR-15, one of these proteins, was identified to interact with certain zinc finger proteins containing KRAB domain through binding zinc finger domain in yeast trap system. This interaction impacts the transcriptional repression of ZNF268, which is one of this type of zinc finger proteins in cells.

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